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Impact of Recently Issued Accounting Standards (Tables)
9 Months Ended
Sep. 30, 2018
Accounting Policies [Abstract]  
Schedule of New Accounting Pronouncements and Changes in Accounting Principles
The cumulative effect of the changes made to the Company's condensed consolidated balance sheet as of January 1, 2018 for the adoption of ASU No. 2016-01 are included in the table below:
Equity:
Balance at December 31, 2017
 
Adjustments due to ASU No. 2016-01
 
Balance at January 1, 2018
Accumulated deficit
$
(523,356,317
)
 
$
231,366

 
$
(523,124,951
)
Accumulated other comprehensive loss
$
(117,005
)
 
$
(231,366
)
 
$
(348,371
)
The following table illustrates the impact that adopting Topic 606 has had on the Company's reported results in the condensed consolidated statement of operations for the three months ended September 30, 2018.
 
Balances Without Adoption of Topic 606 for the Three Months Ended September 30, 2018
 
Impact of Adopting Topic 606
 
As Reported for the Three Months Ended September 30, 2018
Revenues:
 
 
 
 
 
Revenue under collaborative research and development arrangements
$
1,813,287


$

 
$
1,813,287

Revenue under collaborative research and development arrangements with affiliated entities
184,990



 
184,990

Grants and miscellaneous revenue
1,628,433


(1,625,842
)
 
2,591

Grants and miscellaneous revenue from affiliated entity
951,884


(951,884
)
 

Total revenues
4,578,594

 
(2,577,726
)
 
2,000,868

Operating expenses:
 
 
 
 
 
Research and development
24,429,584

 
(2,577,726
)
 
21,851,858

General and administrative
6,791,693

 

 
6,791,693

Total operating expenses
$
31,221,277

 
$
(2,577,726
)
 
$
28,643,551


The following table illustrates the impact that adopting Topic 606 has had on the Company's reported results in the condensed consolidated statement of operations for the nine months ended September 30, 2018.
 
Balances Without Adoption of Topic 606 for the Nine Months Ended September 30, 2018
 
Impact of Adopting Topic 606
 
As Reported for the Nine Months Ended September 30, 2018
Revenues:
 
 
 
 
 
Revenue under collaborative research and development arrangements
$
27,488,185

 
$

 
$
27,488,185

Revenue under collaborative research and development arrangements with affiliated entities
393,317

 

 
393,317

Grants and miscellaneous revenue
3,645,107

 
(3,547,336
)
 
97,771

Grants and miscellaneous revenue from affiliated entity
3,164,454

 
(3,164,454
)
 

Total revenues
34,691,063

 
(6,711,790
)
 
27,979,273

Operating expenses:
 
 
 
 
 
Research and development
75,604,019

 
(6,711,790
)
 
68,892,229

General and administrative
23,679,018

 

 
23,679,018

Total operating expenses
$
99,283,037

 
$
(6,711,790
)
 
$
92,571,247