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Condensed Consolidated Statements of Operations - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Revenues:        
Total revenues $ 2,000,868 $ 2,644,543 $ 27,979,273 $ 33,432,852
Operating expenses:        
Research and development 21,851,858 25,510,239 68,892,229 73,931,494
General and administrative 6,791,693 6,319,775 23,679,018 20,256,470
Total operating expenses 28,643,551 31,830,014 92,571,247 94,187,964
Loss from operations (26,642,683) (29,185,471) (64,591,974) (60,755,112)
Other income (expense):        
Interest and other income, net 380,987 463,346 1,090,191 1,103,708
Change in fair value of common stock warrants 228,665 423,296 360,795 227,273
Gain (loss) on investment in affiliated entities 1,017,359 (5,835,741) 1,305,174 (7,275,462)
Net loss before provision for income taxes (25,015,672) (34,134,570) (61,835,814) (66,699,593)
Provision for income taxes 0 (2,169,811) 0
Net loss $ (25,015,672) $ (34,134,570) $ (64,005,625) $ (66,699,593)
Net loss per share        
Basic (dollars per share) $ (0.27) $ (0.39) $ (0.70) $ (0.85)
Diluted (dollars per share) $ (0.27) $ (0.40) $ (0.70) $ (0.85)
Weighted average number of common shares outstanding        
Basic (shares) 92,423,122 86,952,024 91,350,117 78,894,881
Diluted (shares) 92,423,122 87,090,683 91,350,117 79,043,480
Revenue under collaborative research and development arrangements        
Revenues:        
Total revenues $ 1,813,287 $ 351,272 $ 27,488,185 $ 20,998,174
Revenue under collaborative research and development arrangements with affiliated entities        
Revenues:        
Total revenues 184,990 129,133 393,317 539,342
Grants and miscellaneous revenue        
Revenues:        
Total revenues 2,591 1,456,216 97,771 9,494,096
Grants and miscellaneous revenue from affiliated entity        
Revenues:        
Total revenues $ 0 $ 707,922 $ 0 $ 2,401,240