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Impact of Recently Issued Accounting Standards - Narrative (Details) $ in Thousands	3 Months Ended	9 Months Ended
	Sep. 30, 2018 USD ($)	Sep. 30, 2018 USD ($) lease	Dec. 31, 2017 USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Contra-research and development expense	$ 2,600	$ 6,700
Number of operating leases | lease		3
Accounting Standards Update 2016-01 | AOCI Attributable to Parent
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect			$ (231)
Accounting Standards Update 2016-01 | Retained Earnings
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect			$ (231)
Plumbline Life Sciences
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Gain (loss) on investment in affiliated entities	$ 531	$ 873

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 321
-SubTopic 10
-Section 50
-Paragraph 4
-URI http://asc.fasb.org/extlink&oid=84241550&loc=SL75117546-209714

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