Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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Amount after tax of increase (decrease) to equity or (increase) decrease to net assets, resulting from the cumulative effect adjustment of a new accounting principle applied in the period of adoption.

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Unrecognized cost of unvested share-based compensation awards.

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Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Stock-Based Compensation (Details) - USD ($)	3 Months Ended		9 Months Ended
Stock-Based Compensation (Details) - USD ($)	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017	Jan. 01, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation			$ 8,516,349	$ 10,393,812
Total unrecognized compensation cost related to unvested stock options	$ 6,300,000		$ 6,300,000
Period over which total unrecognized compensation cost related to unvested stock options will be recognized			1 year 10 months 30 days
Weighted average grant date fair value (dollars per share)	$ 2.96	$ 3.95	$ 2.85	$ 4.38
Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total unrecognized compensation cost related to unvested stock options	$ 6,200,000		$ 6,200,000
Period over which total unrecognized compensation cost related to unvested stock options will be recognized			1 year 11 months
Weighted average grant date fair value, restricted stock units (dollars per share)		$ 5.63	$ 4.31	$ 6.68
Employees and Directors
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	$ 2,200,000	$ 2,400,000	$ 8,000,000	$ 10,100,000
Employees and Directors \| Stock Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate	2.86%	1.96%	2.73%	2.21%
Expected volatility	71.00%	73.00%	72.00%	73.00%
Expected life in years	6 years 1 month	6 years 1 month	6 years 2 months	6 years
Dividend yield	0.00%	0.00%	0.00%	0.00%
Non Employee
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock-based compensation	$ 160,000	$ 23,000	$ 334,000	$ 272,000
Research and Development Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share-based compensation expense	1,200,000	1,200,000	4,700,000	4,700,000
General and Administrative Expense
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share-based compensation expense	$ 1,000,000	$ 1,200,000	$ 3,300,000	$ 5,400,000
Retained Earnings \| Accounting Standards Update 2016-09
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Cumulative effect					$ 312,000
Additional Paid-in Capital \| Accounting Standards Update 2016-09
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Cumulative effect					$ (312,000)