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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2018
Income Tax Disclosure [Abstract]  
Schedule of components of income tax expense (benefit)
The components of the provision for income taxes are presented in the following table:
 
 
Year Ended December 31,
 
2018
 
2017
 
2016
Current:
 
 
 
 
 
Federal
$

 
$

 
$

State

 

 

Foreign
2,170,000

 

 

 
2,170,000

 

 

Deferred:
 
 
 
 
 
Federal

 

 


State

 

 

Foreign

 

 

 

 

 

 
$
2,170,000

 
$

 
$

Schedule of effective income tax rate reconciliation
The reconciliation of income taxes attributable to continuing operations computed at the statutory tax rates to income tax expense (recovery), using a 21% statutory tax rate for December 31, 2018, and 35% statutory tax rate for December 31, 2017 and 2016, is as follows:
 
 
Year Ended December 31,
 
2018
 
2017
 
2016
Income (benefit) taxes at statutory rates
$
(19,908,000
)
 
$
(30,872,000
)
 
$
(25,809,000
)
State income tax, net of federal benefit
(4,000
)
 
(4,000
)
 
(4,000
)
Foreign income taxes
2,170,000

 

 

Change in valuation allowance
20,898,000

 
(20,965,000
)
 
29,678,000

Research and development tax credits
(3,170,000
)
 
(3,456,000
)
 
(3,117,000
)
Fair value warrant
(76,000
)
 
(282,000
)
 
(47,000
)
Stock compensation
1,094,000

 
2,332,000

 
113,000

Uncertain tax positions
1,268,000

 
846,000

 
1,367,000

Expired NOLs and credits
2,176,000

 
454,000

 
4,269,000

Limited NOLs and credits
(2,176,000
)
 
(165,000
)
 
(6,456,000
)
Change in tax rates

 
50,019,000

 
(495,000
)
Other
(102,000
)
 
2,093,000

 
501,000

 
$
2,170,000

 
$

 
$

Schedule of deferred tax assets and liabilities
Significant components of the Company’s deferred tax assets and liabilities as of December 31, 2018 and 2017 are shown below:
 
 
As of December 31,
 
2018
 
2017
Deferred tax assets:
 
 
 
Capitalized research expense
$
7,408,000

 
$
8,546,000

Net operating loss carryforwards
89,399,000

 
71,665,000

Research and development and other tax credits
9,432,000

 
7,531,000

Deferred revenue
985,000

 
297,000

Deferred rent
2,013,000

 
2,097,000

Stock-based compensation
3,408,000

 
3,091,000

Acquired intangibles
912,000

 
858,000

Other
2,693,000

 
1,906,000

 
116,250,000

 
95,991,000

Valuation allowance
(115,007,000
)
 
(94,039,000
)
Total deferred tax assets
1,243,000

 
1,952,000

Deferred tax liabilities:
 
 
 
Acquired intangibles
(142,000
)
 
(124,000
)
Investment in affiliated entity
(4,000
)
 
(422,000
)
Fixed assets
(1,121,000
)
 
(1,430,000
)
Net deferred tax liabilities
$
(24,000
)
 
$
(24,000
)
Schedule of operating loss and tax credit carryforward expirations
Based upon statute, federal and state losses and credits are expected to expire as follows (in millions):
Expiration Date:
Federal NOLs
 
State NOLs
 
Federal R&D
 
State R&D
 
 
 
 
 
 
 
 
2019
$
2.4

 
$

 
$

 
$

2020
1.6

 

 

 

2021
2.3

 
0.3

 

 

2022
6.0

 
0.3

 

 

2023
4.5

 
0.4

 

 

2024 and thereafter
280.0

 
143.2

 
13.8

 

Indefinite
86.5

 

 

 
2.7

 
$
383.3

 
$
144.2

 
$
13.8

 
$
2.7

Schedule of unrecognized tax benefits rollforward
The following table summarizes the activity related to the Company's unrecognized tax benefits:
 
 
Year ended December 31,
 
2018
 
2017
 
2016
Balance at beginning of the year
$
8,313,000

 
$
6,855,000

 
$
5,455,000

Increases related to current year tax positions
1,319,000

 
1,532,000

 
1,183,000

Increases (decreases) related to prior year tax positions

 
(74,000
)
 
217,000

Balance at end of the year
$
9,632,000

 
$
8,313,000

 
$
6,855,000