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Summary of Significant Accounting Policies - Calculation of Net Loss Per Share (Details) - USD ($)	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Numerator
Net loss (numerator for use in basic net loss per share)									$ (96,967,830)	$ (88,205,772)	$ (73,740,339)
Adjustment for decrease in fair value of warrant liability									0	(806,819)	0
Numerator for use in diluted net loss per share									$ (96,967,830)	$ (89,012,591)	$ (73,740,339)
Denominator
Weighted average number of common shares outstanding (denominator for use in basic net loss per share) (shares)									92,539,997	81,777,493	73,214,766
Effect of dilutive potential common shares (shares)									0	140,529	0
Denominator for use in diluted loss per share (shares)									92,539,997	81,918,022	73,214,766
Net loss per share, diluted ($ per share)	$ (0.34)	$ (0.27)	$ (0.08)	$ (0.36)	$ (0.24)	$ (0.40)	$ (0.13)	$ (0.31)	$ (1.05)	$ (1.09)	$ (1.01)
Net loss per share, basic ($ per share)	$ (0.34)	$ (0.27)	$ (0.07)	$ (0.36)	$ (0.24)	$ (0.39)	$ (0.13)	$ (0.31)	$ (1.05)	$ (1.08)	$ (1.01)

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