XML 91 R76.htm IDEA: XBRL DOCUMENT v3.19.1
Quarterly Financial Information (Unaudited) (Details) - USD ($)
 3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Disaggregation of Revenue [Line Items]                      
Total revenues $ 2,502,624 $ 2,000,868 $ 24,448,761 $ 1,529,644 $ 8,787,234 $ 2,644,543 $ 20,412,124 $ 10,376,185 $ 30,481,897 $ 42,220,086 $ 35,368,361
Research and development 26,365,647 21,851,858 22,462,620 24,577,751 24,641,124 25,510,239 23,878,751 24,542,504 95,257,876 98,572,618 88,712,035
General and administrative 5,636,141 6,791,693 7,189,310 9,698,015 8,033,899 6,319,775 6,169,106 7,767,589 29,315,159 28,290,369 23,892,263
Gain on sale of assets         1,000,000 0 0 0 0 1,000,000 1,000,000
Total operating expenses 32,001,788 28,643,551 29,651,930 34,275,766 31,675,023 31,830,014 30,047,857 32,310,093 124,573,035 125,862,987 111,604,298
Loss from operations (29,499,164) (26,642,683) (5,203,169) (32,746,122) (22,887,789) (29,185,471) (9,635,733) (21,933,908) (94,091,138) (83,642,901) (76,235,937)
Interest and other income, net (169,300) 380,987 396,681 312,523 509,266 463,346 300,021 340,341 920,891 1,612,974 1,257,257
Change in fair value of common stock warrants 0 228,665 259,971 (127,841) 579,546 423,296 (312,500) 116,477 360,795 806,819 127,554
Gain (loss) from investment in affiliated entity (3,293,741) 1,017,359 (2,092,608) 2,380,423 292,798 (5,835,741) 169,096 (1,608,817) (1,988,567) (6,982,664) 1,110,787
Net loss before provision for income tax (32,962,205) (25,015,672) (6,639,125) (30,181,017)         (94,798,019) (88,205,772) (73,740,339)
Provision for income taxes 0 0 0 2,169,811         2,169,811 0 0
Net loss $ (32,962,205) $ (25,015,672) $ (6,639,125) $ (32,350,828) $ (21,506,179) $ (34,134,570) $ (9,479,116) $ (23,085,907) $ (96,967,830) $ (88,205,772) $ (73,740,339)
Net loss per share                      
Basic ($ per share) $ (0.34) $ (0.27) $ (0.07) $ (0.36) $ (0.24) $ (0.39) $ (0.13) $ (0.31) $ (1.05) $ (1.08) $ (1.01)
Diluted ($ per share) $ (0.34) $ (0.27) $ (0.08) $ (0.36) $ (0.24) $ (0.40) $ (0.13) $ (0.31) $ (1.05) $ (1.09) $ (1.01)
Revenue under collaborative research and development arrangements                      
Disaggregation of Revenue [Line Items]                      
Total revenues $ 2,372,600 $ 1,813,287 $ 24,385,852 $ 1,289,046 $ 7,409,214 $ 351,272 $ 16,358,316 $ 4,288,586 $ 29,860,785 $ 28,407,388 $ 6,490,747
Revenue under collaborative research and development arrangements with affiliated entity                      
Disaggregation of Revenue [Line Items]                      
Total revenues 56,207 184,990 60,319 148,008 226,486 129,133 176,879 233,330 449,524 765,828 1,400,594
Grants and miscellaneous revenue                      
Disaggregation of Revenue [Line Items]                      
Total revenues $ 73,817 $ 2,591 $ 2,590 $ 92,590 980,443 1,456,216 2,797,647 5,240,233 171,588 10,474,539 27,136,457
Grants and miscellaneous revenue from affiliated entity                      
Disaggregation of Revenue [Line Items]                      
Total revenues         $ 171,091 $ 707,922 $ 1,079,282 $ 614,036 $ 0 $ 2,572,331 $ 340,563