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Collaborative Agreements (Details) |  |  |  |  | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | ---
Apr. 11, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 29, 2017 | Aug. 07, 2015 product | Mar. 31, 2018 USD ($) | Sep. 30, 2015 USD ($) | Apr. 30, 2015 USD ($) | Mar. 31, 2019 USD ($) | Mar. 31, 2018 USD ($) | Dec. 31, 2018 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | $ 2,829,905 | $ 1,529,644 |
Deferred grant funding |  |  |  |  |  |  |  | 1,279,005 |  | $ 4,165,848
AstraZeneca |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  |  |  | 2,700,000 | 1,300,000 |
Collaborative Arrangement, Product | ApolloBio |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Territory expansion option period |  |  | 3 years |  |  |  |  |  |  |
Proceeds received in upfront payment |  |  |  |  | $ 19,400,000 |  |  |  |  |
Upfront payment received |  |  |  |  | 23,000,000 |  |  | 23,000,000 |  | $ 23,000,000
Advisory fees |  |  |  |  | 960,000 |  |  |  | 960,000 |
Additional revenue to be achieved |  |  |  |  |  |  |  | $ 20,000,000 |  |
Royalty period |  |  |  |  |  |  |  | 10 years |  |
Period from effective date for termination |  |  |  |  |  |  |  | 1 year |  |
Number of days written notice before termination |  |  |  |  |  |  |  | 90 days |  |
Collaborative Arrangement, Product | AstraZeneca |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Upfront payment received |  | $ 27,500,000 |  |  |  | $ 27,500,000 |  |  |  |
Anticipated development and regulatory event based payment receivable milestones |  |  |  |  |  |  |  | $ 355,000,000 |  |
Anticipated commercial event based payment receivable milestones |  |  |  |  |  |  |  | 345,000,000 |  |
Number of additional products to be developed | product |  |  |  | 2 |  |  |  |  |  |
Deferred revenue |  |  |  |  |  |  |  | 169,000 |  |
Accounts receivable |  |  |  |  |  |  |  | 2,600,000 |  |
Collaborative Arrangement, Product | Coalition for Epidemic Preparedness Innovations |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Collaborative agreement, funding to be received | $ 56,000,000 |  |  |  |  |  |  |  |  |
Collaborative agreement, period to receive funding for research and development | 5 years |  |  |  |  |  |  |  |  |
Funding received for research and development |  |  |  |  |  |  |  | 1,700,000 |  |
Deferred grant funding |  |  |  |  |  |  |  | 424,000 |  |
Collaborative Arrangement, Product | Defense Advanced Research Projects Agency (DARPA) |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Funding received for research and development |  |  |  |  |  |  |  | 96,000 | $ 376,000 |
Base award |  |  |  |  |  |  | $ 19,600,000 |  |  |
Option award |  |  |  |  |  |  | $ 24,600,000 |  |  |
Total funding received for research and development |  |  |  |  |  |  |  | $ 44,200,000 |  |
Foreign Tax Authority | Collaborative Arrangement, Product | ApolloBio |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |
Foreign corporate income taxes reducing upfront payment |  |  |  |  | 2,200,000 |  |  |  |  |
Foreign non-corporate income taxes reducing upfront payment |  |  |  |  | $ 1,400,000 |  |  |  |  |

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