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v3.19.1

Basis of Presentation (Details) - USD ($) |  | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Mar. 01, 2019 | Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |
Net loss |  | $ 29,219,262 | $ 32,350,828 |
Working capital |  | 107,500,000 |  |
Retained earnings (accumulated deficit) |  | (649,645,698) |  | $ (620,426,436)
Cash, cash equivalents, and short-term investments |  | 128,000,000 |  |
Long-term investments |  | 8,700,000 |  |
Proceeds from issuance of stock |  | $ 907,330 | $ 0 |
Geneos Therapeutics, Inc. |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |
Non-controlling interest |  | 39.00% |  |
VGX Animal Health, Inc |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |
Non-controlling interest |  | 15.00% |  |
Common Stock | Sales Agreement |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |
Stock sales agreement, remaining authorized sales amount |  | $ 71,100,000 |  |
Proceeds from issuance of stock |  | 907,000 |  | $ 29,200,000
6.50% Convertible Senior Notes Due 2024 | Convertible Debt |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |
Proceeds from issuance of debt | $ 75,700,000 | 75,700,000 |  |
Principal amount | $ 78,500,000.0 | $ 78,500,000 |  |
Debt instrument, interest rate, stated percentage |  | 6.50% |  |

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