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v3.19.1

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018
Cash flows from operating activities: |  |  |
Net loss | $ (29,288,867) | $ (32,350,828) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 930,907 | 897,709 |
Amortization of intangible assets | 266,563 | 404,062 |
Change in value of common stock warrants | 0 | 127,841 |
Stock-based compensation | 3,432,796 | 3,575,750 |
Non-cash interest expense | 656,248 | 0 |
Amortization of premiums on investments | 1,908 | 55,522 |
Loss on short-term investments | 35,839 | 253,316 |
Loss (gain) on equity investment in affiliated entities | 750,103 | (2,380,423) |
Tax benefit from other unrealized gains on short-term investments | (217,820) | 0 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 533,097 | 855,354 |
Accounts receivable from affiliated entities | (557,154) | (1,755,950) |
Prepaid expenses and other current assets | 19,789 | 598,891 |
Prepaid expenses and other current assets from affiliated entities | (320,741) | 171,026 |
Other assets | (311,272) | 190,726 |
Accounts payable and accrued expenses | (6,999,110) | (6,363,762) |
Accrued clinical trial expenses | 1,487,479 | (183,011) |
Accounts payable and accrued expenses due to affiliated entities | 337,818 | 371,798 |
Deferred revenue | (121,873) | 22,900,404 |
Deferred revenue from affiliated entities | (31,250) | (117,943) |
Operating lease right-of-use assets and liabilities, net | (136,388) | (87,007) |
Deferred grant funding | (2,886,843) | 0 |
Deferred grant funding from affiliated entities | (12,500) | 0 |
Other liabilities | (23,076) | 261,325 |
Net cash used in operating activities | (32,454,347) | (12,575,200) |
Cash flows from investing activities: |  |  |
Purchases of investments | (65,198,491) | (9,568,082) |
Maturities of investments | 16,520,095 | 37,525,434 |
Purchases of capital assets | (658,731) | (1,153,465) |
Net cash (used in) provided by investing activities | (49,337,127) | 26,803,887 |
Cash flows from financing activities: |  |  |
Proceeds from issuance of convertible senior notes | 75,658,953 | 0 |
Proceeds from issuance of common stock, net of issuance costs | 907,330 | 0 |
Taxes paid related to net share settlement of equity awards, net of proceeds from stock option exercises | (719,397) | (506,403) |
Acquisition of non-controlling interest | 3,030,107 | 0 |
Net cash provided by (used in) financing activities | 78,876,993 | (506,403) |
Increase (decrease) in cash and cash equivalents | (2,914,481) | 13,722,284 |
Cash and cash equivalents, beginning of period | 23,693,633 | 23,786,579 | $ 23,786,579
Cash and cash equivalents, end of period | 20,779,152 | 37,508,863 | $ 23,693,633
Supplemental disclosure of non-cash activities |  |  |
Amounts accrued for purchases of property and equipment | $ 68,806 | $ 164,288 |

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- Definition The cash outflow for securities or other assets acquired, which qualify for treatment as an investing activity and are to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from a noncontrolling interest. Includes, but is not limited to, purchase of additional shares or other increase in noncontrolling interest ownership. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585 + Details
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- Definition The cash inflow from sales of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 1A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=114867106&loc=SL7669619-108580 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 1B -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=114867106&loc=SL7669625-108580 Reference 4: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684 Reference 5: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 22 -URI http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599 Reference 6: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591551-111686 Reference 7: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3000-108585 Reference 8: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=108774443&loc=SL4569616-111683 Reference 9: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 280 -SubTopic 10 -Section 50 -Paragraph 32 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=115929826&loc=d3e8933-108599 Reference 10: http://www.xbrl.org/2003/role/exampleRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591552-111686 + Details
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