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Condensed Consolidated Statements of Stockholders' Equity - USD ($) | Total | Preferred stock | Common stock | Additional paid-in capital | Accumulated deficit | Accumulated other comprehensive income (loss) | Non- controlling interest
--- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2017 |  | 23 | 90,357,644 |  |  |  |
Beginning balance at Dec. 31, 2017 | $ 142,488,809 | $ 0 | $ 90,358 | $ 665,775,504 | $ (523,356,317) | $ (117,005) | $ 96,269
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  | 347,287 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments | (506,403) |  | $ 347 | (506,750) |  |  |
Stock-based compensation | 3,575,750 |  |  | 3,575,750 |  |  |
Net loss attributable to common stockholders | (32,350,828) |  |  |  | (32,350,828) |  |
Unrealized gain (loss) on short-term investments, net of tax | (112,765) |  |  |  |  | (112,765) |
Ending balance (in shares) at Mar. 31, 2018 |  | 23 | 90,704,931 |  |  |  |
Ending balance at Mar. 31, 2018 | 113,094,563 | $ 0 | $ 90,705 | 668,844,504 | (555,475,779) | (461,136) | 96,269
Beginning balance (in shares) at Dec. 31, 2017 |  | 23 | 90,357,644 |  |  |  |
Beginning balance at Dec. 31, 2017 | 142,488,809 | $ 0 | $ 90,358 | 665,775,504 | (523,356,317) | (117,005) | 96,269
Net loss attributable to common stockholders | (64,005,625) |  |  |  |  |  |
Unrealized gain (loss) on short-term investments, net of tax | 66,611 |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2018 |  | 23 | 94,472,389 |  |  |  |
Ending balance at Sep. 30, 2018 | 103,709,174 | $ 0 | $ 94,472 | 690,930,769 | (587,130,576) | (281,760) | 96,269
Beginning balance (in shares) at Mar. 31, 2018 |  | 23 | 90,704,931 |  |  |  |
Beginning balance at Mar. 31, 2018 | 113,094,563 | $ 0 | $ 90,705 | 668,844,504 | (555,475,779) | (461,136) | 96,269
Issuance of common stock for cash (in shares) |  |  | 407,429 |  |  |  |
Issuance of common stock for cash | 1,973,401 |  | $ 407 | 1,972,994 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  | 362,035 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments | 611,061 |  | $ 362 | 610,699 |  |  |
Stock-based compensation | 2,589,170 |  |  | 2,589,170 |  |  |
Net loss attributable to common stockholders | (6,639,125) |  |  |  | (6,639,125) |  |
Unrealized gain (loss) on short-term investments, net of tax | (137,250) |  |  |  |  | (137,250) |
Ending balance (in shares) at Jun. 30, 2018 |  | 23 | 91,474,395 |  |  |  |
Ending balance at Jun. 30, 2018 | 111,491,820 | $ 0 | $ 91,474 | 674,017,367 | (562,114,904) | (598,386) | 96,269
Issuance of common stock for cash (in shares) |  |  | 2,560,051 |  |  |  |
Issuance of common stock for cash | 12,949,862 |  | $ 2,560 | 12,947,302 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  | 437,943 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments | 1,615,147 |  | $ 438 | 1,614,709 |  |  |
Stock-based compensation | 2,351,391 |  |  | 2,351,391 |  |  |
Net loss attributable to common stockholders | (25,015,672) |  |  |  | (25,015,672) |  |
Unrealized gain (loss) on short-term investments, net of tax | 316,626 |  |  |  |  | 316,626 |
Ending balance (in shares) at Sep. 30, 2018 |  | 23 | 94,472,389 |  |  |  |
Ending balance at Sep. 30, 2018 | 103,709,174 | $ 0 | $ 94,472 | 690,930,769 | (587,130,576) | (281,760) | 96,269
Beginning balance (in shares) at Dec. 31, 2018 |  | 23 | 97,225,810 |  |  |  |
Beginning balance at Dec. 31, 2018 | 87,032,407 | $ 0 | $ 97,226 | 707,794,215 | (620,426,436) | (528,867) | 96,269
Issuance of common stock for cash (in shares) |  |  | 183,200 |  |  |  |
Issuance of common stock for cash | 907,330 |  | $ 183 | 907,147 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  | 525,000 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments | (719,397) |  | $ 525 | (719,922) |  |  |
Equity component of issuance of convertible notes | 15,752,698 |  |  | 15,752,698 |  |  |
Stock-based compensation | 3,432,796 |  |  | 3,432,796 |  |  |
Acquisition of non-controlling interest in Geneos | 3,030,107 |  |  |  |  |  | 3,030,107
Net loss attributable to common stockholders | (29,288,867) |  |  |  | (29,219,262) |  | (69,605)
Unrealized gain (loss) on short-term investments, net of tax | 819,177 |  |  |  |  | 819,177 |
Ending balance (in shares) at Mar. 31, 2019 |  | 23 | 97,934,010 |  |  |  |
Ending balance at Mar. 31, 2019 | 80,966,251 | $ 0 | $ 97,934 | 727,166,934 | (649,645,698) | 290,310 | 3,056,771
Beginning balance (in shares) at Dec. 31, 2018 |  | 23 | 97,225,810 |  |  |  |
Beginning balance at Dec. 31, 2018 | 87,032,407 | $ 0 | $ 97,226 | 707,794,215 | (620,426,436) | (528,867) | 96,269
Net loss attributable to common stockholders | (82,404,395) |  |  |  |  |  |
Unrealized gain (loss) on short-term investments, net of tax | 1,229,265 |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2019 |  | 23 | 99,046,158 |  |  |  |
Ending balance at Sep. 30, 2019 | 36,118,732 | $ 0 | $ 99,046 | 735,017,743 | (702,123,617) | 700,398 | 2,425,162
Beginning balance (in shares) at Mar. 31, 2019 |  | 23 | 97,934,010 |  |  |  |
Beginning balance at Mar. 31, 2019 | 80,966,251 | $ 0 | $ 97,934 | 727,166,934 | (649,645,698) | 290,310 | 3,056,771
Issuance of common stock for cash (in shares) |  |  | 476,600 |  |  |  |
Issuance of common stock for cash | 1,388,986 |  | $ 476 | 1,388,510 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  | 173,761 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments | (81,259) |  | $ 174 | (81,433) |  |  |
Stock-based compensation | 3,355,195 |  |  | 3,345,378 |  |  | 9,817
Cost of acquisition of non-controlling interest in Geneos | (13,569) |  |  |  |  |  | (13,569)
Net loss attributable to common stockholders | (29,579,076) |  |  |  | (29,387,226) |  | (191,850)
Unrealized gain (loss) on short-term investments, net of tax | 441,545 |  |  |  |  | 441,545 |
Ending balance (in shares) at Jun. 30, 2019 |  | 23 | 98,584,371 |  |  |  |
Ending balance at Jun. 30, 2019 | 56,478,073 | $ 0 | $ 98,584 | 731,819,389 | (679,032,924) | 731,855 | 2,861,169
Issuance of common stock for cash (in shares) |  |  | 382,800 |  |  |  |
Issuance of common stock for cash | 1,128,749 |  | $ 383 | 1,128,366 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  | 78,987 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments | 0 |  | $ 79 | (79) |  |  |
Stock-based compensation | 2,079,819 |  |  | 2,070,067 |  |  | 9,752
Net loss attributable to common stockholders | (23,536,452) |  |  |  | (23,090,693) |  | (445,759)
Unrealized gain (loss) on short-term investments, net of tax | (31,457) |  |  |  |  | (31,457) |
Ending balance (in shares) at Sep. 30, 2019 |  | 23 | 99,046,158 |  |  |  |
Ending balance at Sep. 30, 2019 | $ 36,118,732 | $ 0 | $ 99,046 | $ 735,017,743 | $ (702,123,617) | $ 700,398 | $ 2,425,162

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