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v3.19.3

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2019 | Mar. 31, 2019 | Sep. 30, 2018 | Mar. 31, 2018 | Sep. 30, 2019 | Sep. 30, 2018 | Dec. 31, 2018
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ (23,536,452) | $ (29,288,867) | $ (25,015,672) | $ (32,350,828) | $ (82,404,395) | $ (64,005,625) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Depreciation |  |  |  |  | 2,746,463 | 2,768,096 |
Amortization of intangible assets | 267,000 |  | 267,000 |  | 799,688 | 983,021 |
Change in fair value of common stock warrants |  |  |  |  | 0 | (360,795) |
Change in fair value of derivative liability |  |  |  |  | (2,551,453) | 0 |
Stock-based compensation |  |  |  |  | 8,867,810 | 8,516,349 |
Non-cash interest expense |  |  |  |  | 2,587,619 | 0 |
Amortization of premiums on investments |  |  |  |  | 1,962 | 71,707 |
Loss (gain) on short-term investments |  |  |  |  | (238,083) | 557,875 |
Loss (gain) on equity investment in affiliated entities | 485,841 |  | (1,017,359) |  | 1,409,156 | (1,305,174) |
Tax benefit from other unrealized gains on short-term investments |  |  |  |  | (335,228) | 0 |
Effect of foreign exchange rates on cash and cash equivalents |  |  |  |  | 183,756 | 0 |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Accounts receivable |  |  |  |  | 2,540,066 | 3,171,498 |
Accounts receivable from affiliated entities |  |  |  |  | (239,961) | (1,081,016) |
Prepaid expenses and other current assets |  |  |  |  | (271,012) | 999,047 |
Prepaid expenses and other current assets from affiliated entities |  |  |  |  | (460,306) | (261,187) |
Other assets |  |  |  |  | (61,057) | 13,695 |
Accounts payable and accrued expenses |  |  |  |  | (12,791,123) | (4,888,115) |
Accrued clinical trial expenses |  |  |  |  | (1,170,866) | (1,258,837) |
Accounts payable and accrued expenses due to affiliated entities |  |  |  |  | (515,196) | (236,023) |
Deferred revenue |  |  |  |  | (144,154) | (1,006,745) |
Deferred revenue from affiliated entities |  |  |  |  | 31,250 | (105,685) |
Operating lease right-of-use assets and liabilities, net |  |  |  |  | (622,138) | (277,892) |
Deferred grant funding |  |  |  |  | (2,269,322) | 1,297,416 |
Deferred grant funding from affiliated entities |  |  |  |  | 828,842 | 39,583 |
Other liabilities |  |  |  |  | (35,107) | 99,669 |
Net cash used in operating activities |  |  |  |  | (84,112,789) | (56,269,138) |
Cash flows from investing activities: |  |  |  |  |  |  |
Purchases of investments |  |  |  |  | (86,950,301) | (47,869,250) |
Maturities of investments |  |  |  |  | 68,344,014 | 84,848,556 |
Purchases of capital assets |  |  |  |  | (873,484) | (1,741,955) |
Net cash (used in) provided by investing activities |  |  |  |  | (19,479,771) | 35,237,351 |
Cash flows from financing activities: |  |  |  |  |  |  |
Proceeds from issuance of convertible senior notes and convertible bonds |  |  |  |  | 93,425,973 | 0 |
Costs related to issuance of convertible senior notes and convertible bonds |  |  |  |  | (3,314,757) | 0 |
Proceeds from issuance of common stock, net of issuance costs |  |  |  |  | 3,425,065 | 14,923,263 |
Taxes paid related to net share settlement of equity awards, net of proceeds from stock option exercises |  |  |  |  | (800,656) | 1,719,767 |
Acquisition of non-controlling interest |  |  |  |  | 3,016,538 | 0 |
Net cash provided by financing activities |  |  |  |  | 95,752,163 | 16,643,030 |
Decrease in cash and cash equivalents |  |  |  |  | (7,840,397) | (4,388,757) |
Cash and cash equivalents, beginning of period |  | $ 23,693,633 |  | $ 23,786,579 | 23,693,633 | 23,786,579 | $ 23,786,579
Cash and cash equivalents, end of period | $ 15,853,236 |  | $ 19,397,822 |  | 15,853,236 | 19,397,822 | $ 23,693,633
Supplemental disclosures: |  |  |  |  |  |  |
Amounts accrued for purchases of property and equipment |  |  |  |  | 0 | 188,253 |
Interest paid |  |  |  |  | $ 2,692,083 | $ 0 |

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- Definition Amount of tax expense (benefit), after reclassification adjustments, of appreciation (loss) in value of unsold available-for-sale securities. Excludes amounts related to other than temporary impairment (OTTI) loss. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 10A -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=118930883&loc=SL7669646-108580 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 10A -Subparagraph (f) -URI http://asc.fasb.org/extlink&oid=118930883&loc=SL7669646-108580 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=118930883&loc=d3e640-108580 + Details
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