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v3.20.1

Consolidated Statements of Stockholders' Equity - USD ($) | Total | Preferred stock | Common stock | Additional paid-in capital | Accumulated deficit | Accumulated other comprehensive income (loss) | Non- controlling interest
--- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (shares) at Dec. 31, 2016 |  | 23 | 74,062,370 |  |  |  |
Beginning balance at Dec. 31, 2016 | $ 123,378,420 | $ 0 | $ 74,062 | $ 556,718,356 | $ (434,838,235) | $ 1,327,968 | $ 96,269
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (shares) |  |  | 15,437,406 |  |  |  |
Issuance of common stock for cash, net of financing costs of $4.9 million | 94,347,922 |  | $ 15,437 | 94,332,485 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (shares) |  |  | 857,868 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 1,342,250 |  | $ 859 | 1,341,391 |  |  |
Stock-based compensation | 13,070,962 |  |  | 13,070,962 |  |  |
Net loss attributable to common stockholders | (88,205,772) |  |  |  | (88,205,772) |  |
Unrealized gain on short-term investments, net of tax | 7,458 |  |  |  |  | 7,458 |
Unrealized loss on investment in affiliated entity, net of tax | (1,452,431) |  |  |  |  | (1,452,431) |
Ending balance (shares) at Dec. 31, 2017 |  | 23 | 90,357,644 |  |  |  |
Ending balance at Dec. 31, 2017 | 142,488,809 | $ 0 | $ 90,358 | 665,775,504 | (523,356,317) | (117,005) | 96,269
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (shares) |  |  | 5,669,025 |  |  |  |
Issuance of common stock for cash, net of financing costs of $4.9 million | 29,227,776 |  | $ 5,669 | 29,222,107 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (shares) |  |  | 1,199,141 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 1,809,526 |  | $ 1,199 | 1,808,327 |  |  |
Stock-based compensation | 10,654,622 |  |  | 10,988,277 | (333,655) |  |
Net loss attributable to common stockholders | (96,967,830) |  |  |  | (96,967,830) |  |
Unrealized gain on short-term investments, net of tax | (180,496) |  |  |  |  | (180,496) |
Unrealized loss on investment in affiliated entity, net of tax | 0 |  |  |  |  |  |
Ending balance (shares) at Dec. 31, 2018 |  | 23 | 97,225,810 |  |  |  |
Ending balance at Dec. 31, 2018 | 87,032,407 | $ 0 | $ 97,226 | 707,794,215 | (620,426,436) | (528,867) | 96,269
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (shares) |  |  | 3,340,678 |  |  |  |
Issuance of common stock for cash, net of financing costs of $4.9 million | 9,089,009 |  | $ 3,340 | 9,085,669 |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (shares) |  |  | 794,546 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | (780,405) |  | $ 795 | (781,200) |  |  |
Equity component of issuance of convertible notes | 15,752,698 |  |  | 15,752,698 |  |  |
Stock-based compensation | 10,901,320 |  |  | 10,795,403 |  |  | 105,917
Acquisition of non-controlling interest in Geneos, net | 2,960,131 |  |  |  |  |  | 2,960,131
Net loss attributable to common stockholders | (120,551,777) |  |  |  | (119,359,219) |  | (1,192,558)
Unrealized gain on short-term investments, net of tax | 1,001,475 |  |  |  |  | 1,001,475 |
Unrealized loss on investment in affiliated entity, net of tax | 0 |  |  |  |  |  |
Ending balance (shares) at Dec. 31, 2019 |  | 23 | 101,361,034 |  |  |  |
Ending balance at Dec. 31, 2019 | $ 5,404,858 | $ 0 | $ 101,361 | $ 742,646,785 | $ (739,785,655) | $ 472,608 | $ 1,969,759

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