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v3.20.1

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2020 | Mar. 31, 2019 | Dec. 31, 2019
Cash flows from operating activities: |  |  |
Net loss | $ (33,135,404) | $ (29,288,867) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 809,559 | 930,907 |
Amortization of intangible assets | 136,770 | 266,563 |
Amortization of operating lease right-of-use assets | 271,628 | 0 |
Change in fair value of derivative liability | 13,221,977 | 0 |
Stock-based compensation | 4,001,553 | 3,432,796 |
Non-cash interest expense | 213,559 | 656,248 |
Amortization of premiums on investments | 0 | 1,908 |
Loss on short-term investments | 475,490 | 35,839 |
Settlement of receivable with shares of common stock from affiliated entity (PLS) | (1,713,770) | 0 |
(Gain) loss on equity investment in affiliated entities | (13,181,619) | 750,103 |
Tax benefit from other unrealized gains on short-term investments | 0 | (217,820) |
Unrealized transaction loss on foreign-currency denominated debt | (681,151) | 0 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 58,430 | 533,097 |
Accounts receivable from affiliated entities | 697,846 | (557,154) |
Prepaid expenses and other current assets | (894,606) | 19,789 |
Prepaid expenses and other current assets from affiliated entities | (740,469) | (320,741) |
Other assets | 191,937 | (311,272) |
Accounts payable and accrued expenses | (7,217,676) | (6,999,110) |
Accrued clinical trial expenses | 1,011,439 | 1,487,479 |
Accounts payable and accrued expenses due to affiliated entities | (466,273) | 337,818 |
Deferred revenue | (26,297) | (121,873) |
Deferred revenue from affiliated entities | (31,250) | (31,250) |
Operating lease right-of-use assets and liabilities, net | (517,949) | (136,388) |
Grant funding liability | 7,026,212 | (2,886,843) |
Grant funding liability from affiliated entities | (49,250) | (12,500) |
Other liabilities | 36,501 | (23,076) |
Net cash used in operating activities | (25,452,721) | (32,454,347) |
Cash flows from investing activities: |  |  |
Purchases of investments | (56,698,250) | (65,198,491) |
Proceeds from sale or maturity of investments | 5,030,257 | 16,520,095 |
Purchases of capital assets | (140,952) | (658,731) |
Net cash used in investing activities | (51,808,945) | (49,337,127) |
Cash flows from financing activities: |  |  |
Proceeds from issuance of convertible senior notes | 0 | 75,658,953 |
Proceeds from issuance of common stock, net of issuance costs | 208,241,933 | 907,330 |
Proceeds from stock option exercises | 5,173,534 | 12,334 |
Taxes paid related to net share settlement of equity awards | (2,072,831) | (731,731) |
Acquisition of non-controlling interest | 2,169,998 | 3,030,107 |
Net cash provided by financing activities | 213,512,634 | 78,876,993 |
Increase (Decrease) in cash and cash equivalents | 136,250,968 | (2,914,481) |
Cash and cash equivalents, beginning of period | 22,196,097 | 23,693,633 | $ 23,693,633
Cash and cash equivalents, end of period | 158,447,065 | 20,779,152 | $ 22,196,097
Supplemental disclosures: |  |  |
Amounts accrued for purchases of property and equipment | 0 | 68,806 |
Interest paid | 2,590,196 | 0 |
Right-of-use assets obtained in exchange for lease obligations | $ 0 | $ 14,634,769 |

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