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Condensed Consolidated Statements of Stockholders' Equity - USD ($) | Total | 6.50% Convertible Senior Notes Due 2024 | August 2019 Bonds | Preferred stock | Common stock | Common stock 6.50% Convertible Senior Notes Due 2024 | Common stock August 2019 Bonds | Additional paid-in capital | Additional paid-in capital 6.50% Convertible Senior Notes Due 2024 | Additional paid-in capital August 2019 Bonds | Accumulated deficit | Accumulated other comprehensive income (loss) | Non- controlling interest
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Beginning balance (in shares) at Dec. 31, 2018 |  |  |  | 23 | 97,225,810 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2018 | $ 87,032,407 |  |  | $ 0 | $ 97,226 |  |  | $ 707,794,215 |  |  | $ (620,426,436) | $ (528,867) | $ 96,269
Issuance of common stock for cash (in shares) |  |  |  |  | 183,200 |  |  |  |  |  |  |  |
Issuance of common stock for cash | 907,330 |  |  |  | $ 183 |  |  | 907,147 |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  | 525,000 |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | (719,397) |  |  |  | $ 525 |  |  | (719,922) |  |  |  |  |
Equity component of issuance of convertible notes | 15,752,698 |  |  |  |  |  |  | 15,752,698 |  |  |  |  |
Stock-based compensation | 3,432,796 |  |  |  |  |  |  | 3,432,796 |  |  |  |  |
Acquisition of non-controlling interest in Geneos | 3,030,107 |  |  |  |  |  |  |  |  |  |  |  | 3,030,107
Net loss attributable to common stockholders | (29,288,867) |  |  |  |  |  |  |  |  |  | (29,219,262) |  | (69,605)
Unrealized gain (loss) on short-term investments, net of tax | 819,177 |  |  |  |  |  |  |  |  |  |  | 819,177 |
Ending balance (in shares) at Mar. 31, 2019 |  |  |  | 23 | 97,934,010 |  |  |  |  |  |  |  |
Ending balance at Mar. 31, 2019 | 80,966,251 |  |  | $ 0 | $ 97,934 |  |  | 727,166,934 |  |  | (649,645,698) | 290,310 | 3,056,771
Beginning balance (in shares) at Dec. 31, 2018 |  |  |  | 23 | 97,225,810 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2018 | 87,032,407 |  |  | $ 0 | $ 97,226 |  |  | 707,794,215 |  |  | (620,426,436) | (528,867) | 96,269
Net loss attributable to common stockholders | (82,404,395) |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on short-term investments, net of tax | 1,229,265 |  |  |  |  |  |  |  |  |  |  |  |
Foreign currency translation | 0 |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2019 |  |  |  | 23 | 99,046,158 |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2019 | 36,118,732 |  |  | $ 0 | $ 99,046 |  |  | 735,017,743 |  |  | (702,123,617) | 700,398 | 2,425,162
Beginning balance (in shares) at Mar. 31, 2019 |  |  |  | 23 | 97,934,010 |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2019 | 80,966,251 |  |  | $ 0 | $ 97,934 |  |  | 727,166,934 |  |  | (649,645,698) | 290,310 | 3,056,771
Issuance of common stock for cash (in shares) |  |  |  |  | 476,600 |  |  |  |  |  |  |  |
Issuance of common stock for cash | 1,388,986 |  |  |  | $ 476 |  |  | 1,388,510 |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  | 173,761 |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | (81,259) |  |  |  | $ 174 |  |  | (81,433) |  |  |  |  |
Stock-based compensation | 3,355,195 |  |  |  |  |  |  | 3,345,378 |  |  |  |  | 9,817
Cost of acquisition of non-controlling interest in Geneos | (13,569) |  |  |  |  |  |  |  |  |  |  |  | (13,569)
Net loss attributable to common stockholders | (29,579,076) |  |  |  |  |  |  |  |  |  | (29,387,226) |  | (191,850)
Unrealized gain (loss) on short-term investments, net of tax | 441,545 |  |  |  |  |  |  |  |  |  |  | 441,545 |
Ending balance (in shares) at Jun. 30, 2019 |  |  |  | 23 | 98,584,371 |  |  |  |  |  |  |  |
Ending balance at Jun. 30, 2019 | 56,478,073 |  |  | $ 0 | $ 98,584 |  |  | 731,819,389 |  |  | (679,032,924) | 731,855 | 2,861,169
Issuance of common stock for cash (in shares) |  |  |  |  | 382,800 |  |  |  |  |  |  |  |
Issuance of common stock for cash | 1,128,749 |  |  |  | $ 383 |  |  | 1,128,366 |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  | 78,987 |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 0 |  |  |  | $ 79 |  |  | (79) |  |  |  |  |
Stock-based compensation | 2,079,819 |  |  |  |  |  |  | 2,070,067 |  |  |  |  | 9,752
Net loss attributable to common stockholders | (23,536,452) |  |  |  |  |  |  |  |  |  | (23,090,693) |  | (445,759)
Unrealized gain (loss) on short-term investments, net of tax | (31,457) |  |  |  |  |  |  |  |  |  |  | (31,457) |
Foreign currency translation | 0 |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2019 |  |  |  | 23 | 99,046,158 |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2019 | 36,118,732 |  |  | $ 0 | $ 99,046 |  |  | 735,017,743 |  |  | (702,123,617) | 700,398 | 2,425,162
Beginning balance (in shares) at Dec. 31, 2019 |  |  |  | 23 | 101,361,034 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2019 | 5,404,858 |  |  | $ 0 | $ 101,361 |  |  | 742,646,785 |  |  | (739,785,655) | 472,608 | 1,969,759
Issuance of common stock for cash (in shares) |  |  |  |  | 43,148,952 |  |  |  |  |  |  |  |
Issuance of common stock for cash | 208,241,933 |  |  |  | $ 43,149 |  |  | 208,198,784 |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  | 1,405,114 |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 3,100,703 |  |  |  | $ 1,405 |  |  | 3,099,298 |  |  |  |  |
Stock-based compensation | 4,001,553 |  |  |  |  |  |  | 4,017,761 |  |  |  |  | (16,208)
Acquisition of non-controlling interest in Geneos | 2,169,998 |  |  |  |  |  |  |  |  |  |  |  | 2,169,998
Net loss attributable to common stockholders | (33,135,404) |  |  |  |  |  |  |  |  |  | (32,541,054) |  | (594,350)
Unrealized gain (loss) on short-term investments, net of tax | (1,929,538) |  |  |  |  |  |  |  |  |  |  | (1,929,538) |
Ending balance (in shares) at Mar. 31, 2020 |  |  |  | 23 | 145,915,100 |  |  |  |  |  |  |  |
Ending balance at Mar. 31, 2020 | 187,854,103 |  |  | $ 0 | $ 145,915 |  |  | 957,962,628 |  |  | (772,326,709) | (1,456,930) | 3,529,199
Beginning balance (in shares) at Dec. 31, 2019 |  |  |  | 23 | 101,361,034 |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2019 | 5,404,858 |  |  | $ 0 | $ 101,361 |  |  | 742,646,785 |  |  | (739,785,655) | 472,608 | 1,969,759
Net loss attributable to common stockholders | (143,136,534) |  |  |  |  |  |  |  |  |  |  |  |
Unrealized gain (loss) on short-term investments, net of tax | (726,626) |  |  |  |  |  |  |  |  |  |  |  |
Foreign currency translation | 6,184 |  |  |  |  |  |  |  |  |  |  |  |
Ending balance (in shares) at Sep. 30, 2020 |  |  |  | 9 | 167,528,435 |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2020 | 324,000,115 |  |  | $ 0 | $ 167,527 |  |  | 1,205,842,585 |  |  | (881,858,432) | (247,834) | 96,269
Beginning balance (in shares) at Mar. 31, 2020 |  |  |  | 23 | 145,915,100 |  |  |  |  |  |  |  |
Beginning balance at Mar. 31, 2020 | 187,854,103 |  |  | $ 0 | $ 145,915 |  |  | 957,962,628 |  |  | (772,326,709) | (1,456,930) | 3,529,199
Issuance of common stock for cash (in shares) |  |  |  |  | 12,041,178 |  |  |  |  |  |  |  |
Issuance of common stock for cash | 121,718,922 |  |  |  | $ 12,041 |  |  | 121,706,881 |  |  |  |  |
Conversion of preferred stock to common stock (in shares) |  |  |  | (14) | (5,147) |  |  |  |  |  |  |  |
Conversion of preferred stock to common stock | 0 |  |  |  | $ 5 |  |  | (5) |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  | 794,986 |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 4,422,244 |  |  |  | $ 795 |  |  | 4,421,449 |  |  |  |  |
Stock-based compensation | 3,662,435 |  |  |  |  |  |  | 3,654,289 |  |  |  |  | 8,146
Acquisition of non-controlling interest in Geneos | 209,971 |  |  |  |  |  |  |  |  |  |  |  | 209,971
Deconsolidation of Geneos | (3,181,640) |  |  |  |  |  |  |  |  |  |  |  | (3,181,640)
Net loss attributable to common stockholders | (129,172,466) |  |  |  |  |  |  |  |  |  | (128,703,059) |  | (469,407)
Unrealized gain (loss) on short-term investments, net of tax | 846,900 |  |  |  |  |  |  |  |  |  |  | 846,900 |
Ending balance (in shares) at Jun. 30, 2020 |  |  |  | 9 | 158,756,411 |  |  |  |  |  |  |  |
Ending balance at Jun. 30, 2020 | 186,360,469 |  |  | $ 0 | $ 158,756 |  |  | 1,087,745,242 |  |  | (901,029,768) | (610,030) | 96,269
Conversion of preferred stock to common stock (in shares) |  |  |  |  |  | (3,546,074) | (4,962,364) |  |  |  |  |  |
Conversion of preferred stock to common stock |  | $ 12,971,360 | $ 102,671,310 |  |  | $ 3,546 | $ 4,961 |  | $ 12,967,814 | $ 102,666,349 |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  | 263,586 |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | (1,695,051) |  |  |  | $ 264 |  |  | (1,695,315) |  |  |  |  |
Stock-based compensation | 4,158,495 |  |  |  |  |  |  | 4,158,495 |  |  |  |  |
Net loss attributable to common stockholders | 19,171,336 |  |  |  |  |  |  |  |  |  | 19,171,336 |  |
Unrealized gain (loss) on short-term investments, net of tax | 356,012 |  |  |  |  |  |  |  |  |  |  | 356,012 |
Foreign currency translation | 6,184 |  |  |  |  |  |  |  |  |  |  | 6,184 |
Ending balance (in shares) at Sep. 30, 2020 |  |  |  | 9 | 167,528,435 |  |  |  |  |  |  |  |
Ending balance at Sep. 30, 2020 | $ 324,000,115 |  |  | $ 0 | $ 167,527 |  |  | $ 1,205,842,585 |  |  | $ (881,858,432) | $ (247,834) | $ 96,269

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