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Income Taxes - Narrative (Details) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2019 | Sep. 30, 2019 | Jun. 30, 2019 | Mar. 31, 2019 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Income tax benefit | $ (87,764) | $ 0 | $ (106,771) | $ (62,800) | $ 0 | $ (257,335) | $ 2,169,811
Tax benefits expired |  |  |  |  | 10,200,000 |  |
Unrecognized tax benefits that would impact effective tax rate | $ 9,900,000 |  |  |  | 10,900,000 | $ 9,900,000 | 8,300,000
Federal |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards that will expire due to IRC Section 382 limitations |  |  |  |  | 566,200,000 |  |
Net operating loss carryforwards |  |  |  |  |  |  | $ 270,300,000
Federal | Research Tax Credit Carryforward |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Tax credit carryforward amount |  |  |  |  | 19,800,000 |  |
California |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards that will expire due to IRC Section 382 limitations |  |  |  |  | 68,600,000 |  |
Pennsylvania |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards that will expire due to IRC Section 382 limitations |  |  |  |  | 75,300,000 |  |
State |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Net operating loss carryforwards |  |  |  |  | 143,900,000 |  |
State | Research Tax Credit Carryforward |  |  |  |  |  |  |
Operating Loss Carryforwards [Line Items] |  |  |  |  |  |  |
Tax credit carryforward amount |  |  |  |  | $ 3,200,000 |  |

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