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Income Taxes (Tables)
12 Months Ended
Dec. 31, 2020
Income Tax Disclosure [Abstract]  
Schedule of components of pretax loss from operations
The components of pretax loss from operations are as follows:
Year Ended December 31,
202020192018
     U.S. Domestic$(162,664,355)$(120,809,112)$(94,798,019)
     Foreign(225,949)— — 
Pretax loss from operations$(162,890,304)$(120,809,112)$(94,798,019)
Schedule of components of income tax expense (benefit)
The components of the provision for (benefit from) income taxes are presented in the following table:
Year Ended December 31,
202020192018
Current:
Federal$— $4,000 $— 
State— 2,000 — 
Foreign— — 2,170,000 
— 6,000 2,170,000 
Deferred:
Federal— (263,000)
State— — — 
Foreign— — — 
— (263,000)— 
$— $(257,000)$2,170,000 
Schedule of effective income tax rate reconciliation
The reconciliation of income taxes attributable to continuing operations computed at the statutory tax rates to income tax expense (benefit), using a 21% statutory tax rate for December 31, 2020, 2019 and 2018, is as follows: 
Year Ended December 31,
202020192018
Income (benefit) taxes at statutory rates$(34,207,000)$(25,370,000)$(19,908,000)
State income tax, net of federal benefit— — (4,000)
Foreign income taxes— — 2,170,000 
Change in valuation allowance21,428,000 25,457,000 20,898,000 
Nondeductible loss on extinguishment of debt14,450,000 — — 
Research and development tax credits(2,650,000)(3,838,000)(3,170,000)
Change in fair value of warrants— — (76,000)
Stock-based compensation(1,953,000)1,114,000 1,094,000 
Uncertain tax positions1,068,000 1,537,000 1,268,000 
Deconsolidation of subsidiary853,000 — — 
Expired NOLs and credits468,000 616,000 2,176,000 
Limited NOLs and credits(368,000)(616,000)(2,176,000)
Change in tax rates— 12,000 — 
Foreign tax rate differential(9,000)— — 
Other920,000 831,000 (102,000)
$— $(257,000)$2,170,000 
Schedule of deferred tax assets and liabilities Significant components of the Company’s deferred tax assets and liabilities as of December 31, 2020 and 2019 are shown below:
As of December 31,
20202019
Deferred tax assets:
Capitalized research expense$5,250,000 $6,300,000 
NOL carryforwards127,835,000 110,788,000 
Research and development and other tax credits13,242,000 11,737,000 
Deferred revenue1,628,000 1,506,000 
Stock-based compensation3,256,000 3,255,000 
Acquired intangibles757,000 889,000 
Derivative liability— 1,852,000 
Interest expense 564,000 1,122,000 
Investment in affiliated entity542,000 645,000 
Lease liability4,283,000 4,722,000 
Other6,127,000 2,413,000 
163,484,000 145,229,000 
Valuation allowance(159,705,000)(137,159,000)
Total deferred tax assets3,779,000 8,070,000 
Deferred tax liabilities:
Acquired intangibles(179,000)(160,000)
Right of use asset(2,676,000)(2,894,000)
Note discount(469,000)(2,862,000)
Convertible note— (1,381,000)
Fixed assets(487,000)(805,000)
Net deferred tax liabilities$(32,000)$(32,000)
Schedule of operating loss and tax credit carryforward expirations
Based upon statute, federal and state losses and credits are expected to expire as follows (in millions):
Expiration Date:Federal NOLsState NOLsFederal R&DState R&D
2021$2.3 $0.3 $— $— 
20226.1 0.4 — — 
20235.3 1.2 — — 
202414.5 9.1 — — 
2025 and thereafter267.7 132.9 19.8 — 
Indefinite270.3 — — 3.2 
$566.2 $143.9 $19.8 $3.2 
Schedule of unrecognized tax benefits rollforward
The following table summarizes the activity related to the Company's unrecognized tax benefits:
 Year ended December 31,
 202020192018
Balance at beginning of the year$11,204,000 $9,632,000 $8,313,000 
Increases related to current year tax positions1,043,000 1,575,000 1,319,000 
Increases (decreases) related to prior year tax positions27,000 (3,000)— 
Other(64,000)— — 
Balance at end of the year$12,210,000 $11,204,000 $9,632,000