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v3.21.1

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2021 | Mar. 31, 2020 | Dec. 31, 2020
Cash flows from operating activities: |  |  |
Net loss | $ (54,402,131) | $ (33,135,404) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 660,697 | 809,559 |
Amortization of intangible assets | 136,770 | 136,770 |
Change in fair value of derivative liability | 0 | 13,221,977 |
Stock-based compensation | 9,595,947 | 4,001,553 |
Non-cash interest expense | (31,281) | 213,559 |
Loss on short-term investments | 10,151 | 475,490 |
Settlement of receivable with shares of common stock from affiliated entity (PLS) | 0 | (1,713,770) |
(Gain) loss on equity investment in affiliated entities | 830,475 | (13,181,619) |
Share of net loss in Geneos | 434,387 | 0 |
Net unrealized loss on available-for-sale equity securities | 847,958 | 5,050,092 |
Non-cash lease expense | 278,290 | 0 |
Unrealized transaction loss on foreign-currency denominated debt | (176,927) | (681,151) |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 8,648,045 | 58,430 |
Accounts receivable from affiliated entities | 156,808 | 697,846 |
Prepaid expenses and other current assets | (19,214,780) | (894,606) |
Prepaid expenses and other current assets from affiliated entities | 106,432 | (740,469) |
Other assets | 75,514 | 191,937 |
Accounts payable and accrued expenses | 4,735,352 | (7,217,676) |
Accrued clinical trial expenses | (2,579,476) | 1,011,439 |
Accounts payable and accrued expenses due to affiliated entities | 125,292 | (466,273) |
Deferred revenue | (34,963) | (26,297) |
Deferred revenue from affiliated entities | (37,500) | (31,250) |
Operating lease right-of-use assets and liabilities, net | (558,140) | (517,949) |
Grant funding liability | (2,461,326) | 7,026,212 |
Grant funding liability from affiliated entities | (19,500) | (49,250) |
Other liabilities | 6,478 | 36,501 |
Net cash used in operating activities | (52,867,428) | (25,452,721) |
Cash flows from investing activities: |  |  |
Purchases of investments | (275,408,976) | (56,698,250) |
Proceeds from sale or maturity of investments | 504,464 | 5,030,257 |
Purchases of capital assets | (210,824) | (140,952) |
Net cash used in investing activities | (275,115,336) | (51,808,945) |
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of issuance costs | 162,105,030 | 208,241,933 |
Proceeds from stock option exercises | 2,632,996 | 5,173,534 |
Taxes paid related to net share settlement of equity awards | (3,834,785) | (2,072,831) |
Acquisition of non-controlling interest | 0 | 2,169,998 |
Net cash provided by financing activities | 160,903,241 | 213,512,634 |
Effect of exchange rate changes on cash and cash equivalents | (14,419) | 0 |
Increase (Decrease) in cash and cash equivalents | (167,093,942) | 136,250,968 |
Cash and cash equivalents, beginning of period | 250,728,118 | 22,196,097 | $ 22,196,097
Cash and cash equivalents, end of period | 83,634,176 | 158,447,065 | $ 250,728,118
Supplemental disclosures: |  |  |
Amounts accrued for purchases of property and equipment | 35,370 | 0 |
Interest paid | 544,315 | 2,590,196 |
Amortization Of Operating Lease Right-Of-Use Assets | $ 0 | $ 271,628 |

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