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v3.21.2

Condensed Consolidated Statements of Cash Flows - USD ($) | 6 Months Ended
--- | ---
Jun. 30, 2021 | Jun. 30, 2020
Cash flows from operating activities: |  |
Net loss | $ (136,542,089) | $ (162,307,870)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 1,361,595 | 1,608,060
Amortization of intangible assets | 266,874 | 273,540
Change in fair value of derivative liability | 0 | 110,976,977
Stock-based compensation | 15,242,305 | 7,663,988
Non-cash interest expense | 435,445 | 3,013,942
(Gain) loss on short-term investments | (153,252) | 576,001
Settlement of receivable with shares of common stock from affiliated entity (PLS) | 0 | (1,713,770)
Gain on deconsolidation of Geneos | 0 | 4,121,075
Gain (loss) on equity investment in affiliated entities | 551,657 | (9,298,443)
Share of net loss in Geneos | 434,387 | 901,757
Net unrealized loss on available-for-sale equity securities | 711,465 | 691,458
Non-cash lease expense | 567,882 | 517,865
Unrealized transaction gain on foreign-currency denominated debt | (176,927) | (474,071)
Changes in operating assets and liabilities: |  |
Accounts receivable | 5,431,637 | (2,813,086)
Accounts receivable from affiliated entities | (219,159) | 865,832
Prepaid expenses and other current assets | (51,944,060) | (3,084,082)
Prepaid expenses and other current assets from affiliated entities | (197,059) | (1,330,601)
Other assets | 24,126,582 | 116,242
Accounts payable and accrued expenses | 8,891,770 | (732,774)
Accrued clinical trial expenses | 465,819 | 2,882,486
Accounts payable and accrued expenses due to affiliated entities | 1,130,877 | 4,634
Deferred revenue | 55,074 | (92,426)
Deferred revenue from affiliated entities | (6,250) | 62,500
Operating lease right-of-use assets and liabilities, net | (1,131,555) | (1,022,951)
Grant funding liability | (615,155) | 4,265,023
Grant funding liability from affiliated entities | (21,000) | (63,050)
Other liabilities | 6,478 | 29,686
Net cash used in operating activities | (131,326,659) | (52,604,208)
Cash flows from investing activities: |  |
Purchases of investments | (307,857,113) | (138,698,249)
Proceeds from sale or maturity of investments | 83,466,967 | 47,455,067
Purchases of capital assets | (418,734) | (176,534)
Decrease in cash resulting from the deconsolidation of Geneos | 0 | 2,774,851
Net cash used in investing activities | (224,808,880) | (94,194,567)
Cash flows from financing activities: |  |
Proceeds from issuance of common stock, net of issuance costs | 162,105,030 | 329,960,855
Proceeds from stock option exercises | 6,154,794 | 9,599,514
Taxes paid related to net share settlement of equity awards | (3,915,160) | (2,076,567)
Acquisition of non-controlling interest | 0 | 2,379,969
Proceeds from Geneos issuance of note payable | 0 | 171,620
Net cash provided by financing activities | 164,344,664 | 340,035,391
Effect of exchange rate changes on cash and cash equivalents | (11,941) | 0
(Decrease) Increase in cash and cash equivalents | (191,802,816) | 193,236,616
Cash and cash equivalents, beginning of period | 250,728,118 | 22,196,097
Cash and cash equivalents, end of period | 58,925,302 | 215,432,713
Supplemental disclosures: |  |
Amounts accrued for purchases of property and equipment | 0 | 1,620
Interest paid | $ 544,315 | $ 2,636,454

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