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Stock-Based Compensation (Details) - USD ($)
3 Months Ended 6 Months Ended
Aug. 28, 2020
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock-based compensation       $ 15,242,305 $ 7,663,988
Total unrecognized compensation cost related to unvested stock options   $ 19,800,000   $ 19,800,000  
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years)       2 years 3 months 18 days  
Weighted average grant date fair value (in dollars per share)   $ 5.25 $ 9.52 $ 7.91 $ 6.19
2016 Incentive Plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Award vesting period (in years)       3 years  
Research and Development Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Allocated share-based compensation expense   $ 2,700,000 $ 1,800,000 $ 7,900,000 $ 4,100,000
General and Administrative Expense          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Allocated share-based compensation expense   2,600,000 1,600,000 6,600,000 3,000,000.0
Employees and Directors          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock-based compensation   5,300,000 3,400,000 14,500,000 7,100,000
Non Employee          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Stock-based compensation   $ 308,000 $ 224,000 $ 737,000 $ 607,000
Stock Options | Employees and Directors          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Risk-free interest rate   0.99% 0.40% 0.90% 0.67%
Expected volatility   93.00% 80.00% 92.00% 77.00%
Expected life in years   5 years 8 months 12 days 5 years 10 months 24 days 5 years 9 months 18 days 5 years 10 months 24 days
Dividend yield   0.00% 0.00% 0.00% 0.00%
Performance-based restricted stock units          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Total unrecognized compensation cost related to unvested stock options   $ 16,800,000   $ 16,800,000  
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years)       2 years 1 month 6 days  
Weighted average grant date fair value, restricted stock units (in dollars per share)   $ 6.81 $ 14.50 $ 10.64 $ 9.12
Performance-based restricted stock units | 2016 Incentive Plan          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Weighted average grant date fair value, restricted stock units (in dollars per share) $ 12.06        
Granted (in shares) 663,353        
Grant date fair value $ 8,000,000.0        
Performance-based restricted stock units | 2016 Incentive Plan | Tranche One          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage 50.00%        
Performance-based restricted stock units | 2016 Incentive Plan | Tranche Two          
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]          
Vesting percentage 50.00%        
Award vesting period (in years) 1 year