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Income Taxes Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Capitalized research expense | $ 4,200 | $ 5,250
NOL carryforwards | 197,144 | 127,835
Research and development and other tax credits | 23,005 | 13,242
Deferred revenue | 987 | 1,628
Stock-based compensation | 3,599 | 3,256
Acquired intangibles | 637 | 757
Interest expense | 83 | 564
Investment in affiliated entity | 750 | 542
Lease liability | 3,793 | 4,283
Other | 5,973 | 6,127
Deferred tax assets, gross | 240,171 | 163,484
Valuation allowance | (237,205) | (159,705)
Total deferred tax assets | 2,966 | 3,779
Deferred tax liabilities: |  |
Acquired intangibles | (194) | (179)
Right of use asset | (2,430) | (2,676)
Note discount | (321) | (469)
Fixed assets | (53) | (487)
Net deferred tax liabilities | $ (32) | $ (32)

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