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Summary of Significant Accounting Policies - Antidilutive Securities Table (Details) - shares
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 16,654,503 16,190,768 30,737,956
Options to purchase common stock      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 10,488,993 8,906,624 9,265,390
Service-based restricted stock units      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 2,448,868 2,558,052 2,069,936
Performance-based restricted stock units      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 663,353 663,353 0
Convertible preferred stock      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 3,309 3,309 8,456
Convertible Debt Securities | 6.50% Convertible Senior Notes Due 2024      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 3,049,980 3,049,980 14,585,653
Convertible Debt Securities | August 2019 Bonds      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 0 0 3,799,071
Convertible Debt Securities | December 2019 Bonds      
Summary of common shares that were excluded from the diluted net loss per share calculation because of their anti-dilutive effect      
Total antidilutive securities (shares) 0 1,009,450 1,009,450