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Summary of Significant Accounting Policies - Summary of Stock-Based Compensation Assumptions (Details) - Stock Options	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Employees and Directors
Summary of assumptions used to estimate the fair value of stock options
Risk-free interest rate	0.91%	0.63%	2.42%
Expected volatility	93.00%	78.00%	70.00%
Expected life in years	6 years	6 years	6 years
Dividend yield	0.00%	0.00%	0.00%
Non Employee
Summary of assumptions used to estimate the fair value of stock options
Risk-free interest rate	1.45%	0.82%	2.45%
Expected volatility	87.00%	76.00%	88.00%
Expected life in years	10 years	10 years	10 years
Dividend yield	0.00%	0.00%	0.00%

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- Definition

Assumptions used in estimation of fair value of stock options.

+ References

No definition available.

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- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iii)
-URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901

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The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
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- Definition

The risk-free interest rate assumption that is used in valuing an option on its own shares.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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