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Consolidated Statements of Comprehensive Loss - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Statement of Comprehensive Income [Abstract]
Net loss	$ (303,658,710)	$ (167,474,914)	$ (120,551,777)
Other comprehensive income (loss):
Foreign currency translation	(30,134)	27,205	0
Unrealized gain (loss) on short-term investments, net of tax	4,048	(755,963)	1,001,475
Comprehensive loss	(303,684,796)	(168,203,672)	(119,550,302)
Comprehensive loss attributable to non-controlling interest	0	1,063,757	1,192,558
Comprehensive loss attributable to Inovio Pharmaceuticals, Inc.	$ (303,684,796)	$ (167,139,915)	$ (118,357,744)

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