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Income Taxes - Reconciliation of Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]
Income (benefit) taxes at statutory rates	$ (63,677)	$ (34,207)	$ (25,370)
State income tax, net of federal benefit	(3,447)	0	0
Change in valuation allowance	77,424	21,428	25,457
Nondeductible loss on extinguishment of debt	0	14,450	0
Research and development tax credits	(16,523)	(2,650)	(3,838)
Stock-based compensation	483	(1,953)	1,114
Uncertain tax positions	6,509	1,068	1,537
Deconsolidation of subsidiary	0	853	0
Expired NOLs and credits	616	468	616
Limited NOLs and credits	(542)	(368)	(616)
Change in tax rates	0	0	12
Foreign tax rate differential	(24)	(9)	0
Other	(819)	920	831
Income tax expense (benefit)	$ 0	$ 0	$ (257)

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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-Publisher FASB
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-Section 50
-Paragraph 12
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