Income Taxes Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Capitalized research expense	$ 4,200	$ 5,250
NOL carryforwards	197,144	127,835
Research and development and other tax credits	23,005	13,242
Deferred revenue	987	1,628
Stock-based compensation	3,599	3,256
Acquired intangibles	637	757
Interest expense	83	564
Investment in affiliated entity	750	542
Lease liability	3,793	4,283
Other	5,973	6,127
Deferred tax assets, gross	240,171	163,484
Valuation allowance	(237,205)	(159,705)
Total deferred tax assets	2,966	3,779
Deferred tax liabilities:
Acquired intangibles	(194)	(179)
Right of use asset	(2,430)	(2,676)
Note discount	(321)	(469)
Fixed assets	(53)	(487)
Net deferred tax liabilities	$ (32)	$ (32)

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from in-process research and development costs expensed in connection with a business combination.

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from investments (excludes investments in subsidiaries and equity method investments).

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Amount, after deferred tax asset, of deferred tax liability attributable to taxable differences without jurisdictional netting.

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Amount of deferred tax liability attributable to taxable temporary differences from property, plant, and equipment.

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