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v3.22.1

Basis of Presentation, Liquidity and Risks and Uncertainties (Details) - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Net loss | $ 79,073,719 | $ 54,402,131 |
Working capital | 340,500,000 |  |
Accumulated deficit | 1,287,103,438 |  | $ 1,209,855,522
Cash, cash equivalents, and short-term investments | 360,400,000 |  |
Proceeds from issuance of stock | 29,364,538 | $ 162,105,030 |
Common stock | Sales Agreements |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Proceeds from issuance of stock | 29,400,000 |  | $ 47,700,000
Common stock | Underwritten Public Offering |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |
Proceeds from issuance of stock | $ 162,100,000 |  |

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