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Basis of Presentation, Liquidity and Risks and Uncertainties (Details) - USD ($)
 3 Months Ended 12 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Net loss $ 79,073,719 $ 54,402,131  
Working capital 340,500,000    
Accumulated deficit 1,287,103,438   $ 1,209,855,522
Cash, cash equivalents, and short-term investments 360,400,000    
Proceeds from issuance of stock 29,364,538 $ 162,105,030  
Common stock | Sales Agreements      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Proceeds from issuance of stock 29,400,000   $ 47,700,000
Common stock | Underwritten Public Offering      
New Accounting Pronouncements or Change in Accounting Principle [Line Items]      
Proceeds from issuance of stock $ 162,100,000