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Stock-Based Compensation (Details) - USD ($)
3 Months Ended
Aug. 28, 2020
Mar. 31, 2022
Mar. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock-based compensation   $ 7,711,151 $ 9,595,947
Total unrecognized compensation cost related to unvested stock options   $ 19,800,000  
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years)   2 years 2 months 12 days  
Weighted average grant date fair value (in dollars per share)   $ 2.48 $ 8.34
2016 Incentive Plan      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Award vesting period (in years)   3 years  
Research and Development Expense      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Allocated share-based compensation expense   $ 3,700,000 $ 5,200,000
General and Administrative Expense      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Allocated share-based compensation expense   3,500,000 4,000,000
Employees and Directors      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock-based compensation   7,200,000 9,200,000
Non Employee      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Stock-based compensation   $ 550,000 $ 429,000
Stock Options | Employees and Directors      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Risk-free interest rate   1.88% 0.88%
Expected volatility   93.00% 92.00%
Expected life in years   5 years 8 months 12 days 5 years 9 months 18 days
Dividend yield   0.00% 0.00%
Performance-based restricted stock units      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Total unrecognized compensation cost related to unvested stock options   $ 17,100,000  
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years)   2 years 1 month 6 days  
Weighted average grant date fair value, restricted stock units (in dollars per share)   $ 3.33 $ 11.42
Performance-based restricted stock units | 2016 Incentive Plan      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Weighted average grant date fair value, restricted stock units (in dollars per share) $ 12.06    
Granted (in shares) 663,353    
Grant date fair value $ 8,000,000    
Performance-based restricted stock units | 2016 Incentive Plan | Tranche One      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Vesting percentage 50.00%    
Performance-based restricted stock units | 2016 Incentive Plan | Tranche Two      
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]      
Vesting percentage 50.00%    
Award vesting period (in years) 1 year