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v3.22.2

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2022 | Mar. 31, 2022 | Jun. 30, 2021 | Mar. 31, 2021 | Jun. 30, 2022 | Jun. 30, 2021 | Dec. 31, 2021
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ (108,497,311) | $ (79,073,719) | $ (82,139,958) | $ (54,402,131) | $ (187,571,030) | $ (136,542,089) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Depreciation |  |  |  |  | 1,869,961 | 1,361,595 |
Amortization of intangible assets | 131,000 |  | 130,000 |  | 257,327 | 266,874 |
Amortization of operating lease right-of-use assets |  |  |  |  | 658,501 | 567,882 |
Non-cash stock-based compensation |  |  |  |  | 16,047,204 | 15,242,305 |
Non-cash interest expense |  |  |  |  | 93,489 | 435,445 |
Amortization of premiums on investments |  |  |  |  | (72,833) | 0 |
(Gain) loss on short-term investments |  |  |  |  | 320,942 | (153,252) |
Loss on disposal of fixed assets |  |  |  |  | 157,666 | 0 |
Gain on remeasurement of investment in Geneos |  |  |  |  | (165,215) | 0 |
Loss on equity investment in affiliated entities | 934,015 |  | (278,818) |  | 1,471,743 | 551,657 |
Share of net loss in Geneos | 0 |  | 0 |  | 2,165,213 | 434,387 |
Net unrealized loss on available-for-sale equity securities | 3,967,101 |  | (136,493) |  | 8,807,742 | 711,465 |
Unrealized transaction gain on foreign-currency denominated debt |  |  |  |  | 0 | (176,927) |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Accounts receivable, including from affiliated entities |  |  |  |  | (3,339,490) | 5,212,478 |
Prepaid expenses and other current assets, including from affiliated entities |  |  |  |  | (17,590,402) | (52,141,119) |
Other assets |  |  |  |  | 655,650 | 24,126,582 |
Accounts payable and accrued expenses, including due to affiliated entities |  |  |  |  | 58,090,822 | 10,022,647 |
Accrued clinical trial expenses |  |  |  |  | (203,397) | 465,819 |
Deferred revenue, including from affiliated entity |  |  |  |  | 8,953,565 | 48,824 |
Operating lease right-of-use assets and liabilities, net |  |  |  |  | (1,272,391) | (1,131,555) |
Grant funding liability, including from affiliated entity |  |  |  |  | (1,730,316) | (636,155) |
Other liabilities |  |  |  |  | (14,826) | 6,478 |
Net cash used in operating activities |  |  |  |  | (112,410,075) | (131,326,659) |
Cash flows from investing activities: |  |  |  |  |  |  |
Purchases of investments |  |  |  |  | (139,377,240) | (307,857,113) |
Proceeds from sale or maturity of investments |  |  |  |  | 153,122,784 | 83,466,967 |
Purchases of capital assets |  |  |  |  | (717,212) | (418,734) |
Investment in Geneos |  |  |  |  | (1,999,998) | 0 |
Net cash provided by (used in) investing activities |  |  |  |  | 11,028,334 | (224,808,880) |
Cash flows from financing activities: |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  |  |  | 72,521,372 | 162,105,030 |
Proceeds from stock option exercises |  |  |  |  | 189,522 | 6,154,794 |
Taxes paid related to net share settlement of equity awards |  |  |  |  | (1,349,733) | (3,915,160) |
Net cash provided by financing activities |  |  |  |  | 71,361,161 | 164,344,664 |
Effect of exchange rate changes on cash and cash equivalents |  |  |  |  | (21,340) | (11,941) |
Decrease in cash and cash equivalents |  |  |  |  | (30,041,920) | (191,802,816) |
Cash and cash equivalents, beginning of period |  | $ 71,143,778 |  | $ 250,728,118 | 71,143,778 | 250,728,118 | $ 250,728,118
Cash and cash equivalents, end of period | $ 41,101,858 |  | $ 58,925,302 |  | 41,101,858 | 58,925,302 | $ 71,143,778
Supplemental disclosures: |  |  |  |  |  |  |
Amounts accrued for purchases of fixed assets |  |  |  |  | 67,645 | 0 |
Interest paid |  |  |  |  | $ 533,487 | $ 544,315 |

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