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Stock-Based Compensation - Narrative (Details) - USD ($) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2022 | Jun. 30, 2021 | Jun. 30, 2022 | Jun. 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Non-cash stock-based compensation |  |  | $ 16,047,204 | $ 15,242,305
Total unrecognized compensation cost related to unvested stock options | $ 15,500,000 |  | $ 15,500,000 |
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years) |  |  | 2 years |
Weighted average grant date fair value (in dollars per share) | $ 1.66 | $ 5.25 | $ 2.35 | $ 7.91
Employees and Directors |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Non-cash stock-based compensation | $ 8,800,000 | $ 5,300,000 | $ 16,000,000 | $ 14,500,000
Employees and Directors | Research and Development Expense |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Allocated share-based compensation expense | 2,200,000 | 2,700,000 | 5,900,000 | 7,900,000
Employees and Directors | General and Administrative Expense |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Allocated share-based compensation expense | 6,600,000 | 2,600,000 | 10,100,000 | 6,600,000
Non Employee |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Non-cash stock-based compensation | 415,000 | $ 308,000 | $ 965,000 | $ 737,000
J. Joseph Kim |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Settled in cash percentage |  |  | 50.00% |
Settled in shares percentage |  |  | 50.00% |
Restricted Stock Units |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Non-cash stock-based compensation |  |  | $ 0 |
Total unrecognized compensation cost related to unvested stock options | $ 11,600,000 |  | $ 11,600,000 |
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years) |  |  | 2 years |
Weighted average grant date fair value, restricted stock units (in dollars per share) | $ 2.14 | $ 6.81 | $ 3.12 | $ 10.64
Number of shares of unvested restricted stock units and options outstanding (in shares) | 111,941 |  | 111,941 |
Stock Options |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Allocated share-based compensation expense | $ 4,200,000 |  | $ 4,200,000 |
Stock Options | J. Joseph Kim |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |
Expiration period |  |  | 5 years |

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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