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Commitments and Contingencies - Narrative (Details) $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Dec. 31, 2019 ft² agreement	Jun. 30, 2022 USD ($) ft²	Jun. 30, 2021 USD ($)	Mar. 09, 2021 USD ($)
Lessee, Lease, Description [Line Items]
Lease cost	$ 851	$ 827		$ 1,700	$ 1,700
Number of agreements | agreement			2
McDermid v. Inovio Pharmaceuticals, Inc. and J. Joseph Kim
Lessee, Lease, Description [Line Items]
Estimate of cash settlement						$ 30,000
Estimate of shares settlement						$ 14,000
Minimum
Lessee, Lease, Description [Line Items]
Operating lease, remaining lease term	1 year 4 months 24 days			1 year 4 months 24 days
Maximum
Lessee, Lease, Description [Line Items]
Operating lease, remaining lease term	7 years 6 months			7 years 6 months
San Diego, California
Lessee, Lease, Description [Line Items]
Area leased (in square feet) | ft²				82,200
Plymouth Meeting, Pennsylvania
Lessee, Lease, Description [Line Items]
Area leased (in square feet) | ft²			13,500	57,360

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