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v3.22.2.2

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2022 | Mar. 31, 2022 | Sep. 30, 2021 | Mar. 31, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ (37,783,896) | $ (79,073,719) | $ (60,169,041) | $ (54,402,131) | $ (225,354,926) | $ (196,711,130) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Depreciation |  |  |  |  | 2,776,672 | 2,094,896 |
Amortization of intangible assets | 120,000 |  | 127,000 |  | 376,911 | 393,644 |
Amortization of operating lease right-of-use assets |  |  |  |  | 993,949 | 863,060 |
Non-cash stock-based compensation |  |  |  |  | 19,281,108 | 20,862,757 |
Non-cash interest on senior convertible notes |  |  |  |  | (126,511) | 378,331 |
Amortization of (discounts) premiums on investments |  |  |  |  | (584,816) | 1,150,985 |
(Gain) loss on short-term investments |  |  |  |  | 1,265,669 | (117,877) |
Loss on disposal of fixed assets |  |  |  |  | 157,666 | 0 |
Gain on remeasurement of investment in Geneos |  |  |  |  | (165,215) | 0 |
Loss on equity investment in affiliated entities | 305,061 |  | 21,999 |  | 1,776,804 | 573,656 |
Share of net loss in Geneos | 0 |  | 0 |  | 2,165,213 | 434,387 |
Net unrealized loss on available-for-sale equity securities | 1,833,284 |  | 455,299 |  | 10,641,026 | 1,166,764 |
Unrealized transaction gain on foreign-currency denominated debt |  |  |  |  | 0 | (176,927) |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Accounts receivable, including from affiliated entities |  |  |  |  | (2,048,642) | 11,938,660 |
Prepaid expenses and other current assets, including from affiliated entities |  |  |  |  | (19,146,007) | (52,576,760) |
Other assets |  |  |  |  | 723,808 | 24,202,365 |
Accounts payable and accrued expenses, including due to affiliated entities |  |  |  |  | 27,323,827 | 7,270,652 |
Accrued clinical trial expenses |  |  |  |  | 3,159,580 | 3,668,480 |
Deferred revenue, including from affiliated entity |  |  |  |  | (85,989) | 20,111 |
Operating lease right-of-use assets and liabilities, net |  |  |  |  | (1,930,270) | (1,723,265) |
Grant funding liability, including from affiliated entity |  |  |  |  | (1,770,768) | (1,536,629) |
Other liabilities |  |  |  |  | 695,522 | 6,478 |
Net cash used in operating activities |  |  |  |  | (179,875,389) | (177,817,362) |
Cash flows from investing activities: |  |  |  |  |  |  |
Purchases of investments |  |  |  |  | (203,549,807) | (308,464,967) |
Proceeds from sale or maturity of investments |  |  |  |  | 261,938,897 | 140,201,825 |
Purchases of capital assets |  |  |  |  | (804,044) | (587,348) |
Investment in Geneos |  |  |  |  | (1,999,998) | 0 |
Net cash provided by (used in) investing activities |  |  |  |  | 55,585,048 | (168,850,490) |
Cash flows from financing activities: |  |  |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  |  |  | 76,287,314 | 162,105,030 |
Proceeds from stock option exercises |  |  |  |  | 283,022 | 6,410,202 |
Taxes paid related to net share settlement of equity awards |  |  |  |  | (1,397,631) | (4,611,348) |
Net cash provided by financing activities |  |  |  |  | 75,172,705 | 163,903,884 |
Effect of exchange rate changes on cash and cash equivalents |  |  |  |  | (37,903) | (22,813) |
Decrease in cash and cash equivalents |  |  |  |  | (49,155,539) | (182,786,781) |
Cash and cash equivalents, beginning of period |  | $ 71,143,778 |  | $ 250,728,118 | 71,143,778 | 250,728,118 | $ 250,728,118
Cash and cash equivalents, end of period | $ 21,988,239 |  | $ 67,941,337 |  | 21,988,239 | 67,941,337 | $ 71,143,778
Supplemental disclosures: |  |  |  |  |  |  |
Amounts accrued for purchases of fixed assets |  |  |  |  | 262,191 | 29,080 |
Interest paid |  |  |  |  | 1,066,975 | 1,077,803 |
Change in prepaid expenses and other current assets included in fixed assets |  |  |  |  | $ 0 | $ 7,709,337 |

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