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Stock-Based Compensation - Narrative (Details) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Non-cash stock-based compensation     $ 19,281,108 $ 20,862,757
Allocated share-based compensation expense     4,200,000  
Total unrecognized compensation cost related to unvested stock options $ 11,400,000   $ 11,400,000  
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years)     1 year 9 months 18 days  
Weighted average grant date fair value (in dollars per share) $ 1.73 $ 6.40 $ 2.34 $ 7.75
Employees and Directors        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Non-cash stock-based compensation $ 3,000,000 $ 5,300,000 $ 19,000,000 $ 19,800,000
Employees and Directors | Research and Development Expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated share-based compensation expense 1,400,000 2,800,000 7,300,000 10,700,000
Employees and Directors | General and Administrative Expense        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Allocated share-based compensation expense 1,600,000 2,500,000 11,700,000 9,100,000
Non Employee        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Non-cash stock-based compensation 235,000 $ 311,000 $ 1,200,000 $ 1,000,000
J. Joseph Kim        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Settled in cash percentage     50.00%  
Settled in shares percentage     50.00%  
Restricted Stock Units        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Non-cash stock-based compensation     $ 0  
Total unrecognized compensation cost related to unvested stock options $ 9,200,000   $ 9,200,000  
Period over which total unrecognized compensation cost related to unvested stock options will be recognized (in years)     1 year 9 months 18 days  
Weighted average grant date fair value, restricted stock units (in dollars per share) $ 2.29 $ 8.63 $ 3.12 $ 10.37
Number of shares of unvested restricted stock units and options outstanding (in shares) 111,941   111,941  
Stock Options | J. Joseph Kim        
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]        
Expiration period     5 years