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Consolidated Statements of Stockholders' Equity - USD ($) | Total | Adjustment | 6.50% Convertible Senior Notes Due 2024 | August 2019 Bonds | Preferred stock | Common stock | Common stock 6.50% Convertible Senior Notes Due 2024 | Common stock August 2019 Bonds | Additional paid-in capital | Additional paid-in capital Adjustment | Additional paid-in capital 6.50% Convertible Senior Notes Due 2024 | Additional paid-in capital August 2019 Bonds | Accumulated deficit | Accumulated deficit Adjustment | Accumulated other comprehensive income (loss) | Non- controlling interest
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2019 |  |  |  |  | 23 | 101,361,034 |  |  |  |  |  |  |  |  |  |
Beginning balance at Dec. 31, 2019 | $ 5,404,858 |  |  |  | $ 0 | $ 101,361 |  |  | $ 742,646,785 |  |  |  | $ (739,785,655) |  | $ 472,608 | $ 1,969,759
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) |  |  |  |  |  | 66,064,886 |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs | 454,486,400 |  |  |  |  | $ 66,065 |  |  | 454,420,335 |  |  |  |  |  |  |
Conversion of preferred stock/senior notes to common stock (in shares) |  |  |  |  | (14) | 5,147 | 11,535,660 | 4,962,364 |  |  |  |  |  |  |  |
Conversion of preferred stock/senior notes to common stock | 0 |  | $ 43,694,386 | $ 102,671,310 |  | $ 5 | $ 11,536 | $ 4,961 | (5) |  | $ 43,682,850 | $ 102,666,349 |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  |  | 2,922,402 |  |  |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 8,241,624 |  |  |  |  | $ 2,923 |  |  | 8,238,701 |  |  |  |  |  |  |
Stock-based compensation | 15,647,523 |  |  |  |  |  |  |  | 15,655,585 |  |  |  |  |  |  | (8,062)
Acquisition of non-controlling interest in Geneos, net | 2,379,969 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,379,969
Deconsolidation of Geneos | (3,181,640) |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (3,181,640)
Net loss attributable to common stockholders | (167,474,914) |  |  |  |  |  |  |  |  |  |  |  | (166,411,157) |  |  | (1,063,757)
Dissolution of majority-owned subsidiary VGX Animal Health, Inc. | 0 |  |  |  |  |  |  |  | 96,269 |  |  |  |  |  |  | (96,269)
Unrealized loss on short-term investments, net of tax | (755,963) |  |  |  |  |  |  |  |  |  |  |  |  |  | (755,963) |
Foreign currency translation | 27,205 |  |  |  |  |  |  |  |  |  |  |  |  |  | 27,205 |
Ending balance (in shares) at Dec. 31, 2020 |  |  |  |  | 9 | 186,851,493 |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2020 | 461,140,758 |  |  |  | $ 0 | $ 186,851 |  |  | 1,367,406,869 |  |  |  | (906,196,812) |  | (256,150) | 0
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) |  |  |  |  |  | 27,310,341 |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs | 209,441,410 |  |  |  |  | $ 27,310 |  |  | 209,414,100 |  |  |  |  |  |  |
Conversion of preferred stock/senior notes to common stock (in shares) |  |  |  |  |  | 1,009,450 |  |  |  |  |  |  |  |  |  |
Conversion of preferred stock/senior notes to common stock | 4,377,892 |  |  |  |  | $ 1,009 |  |  | 4,376,883 |  |  |  |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  |  | 2,211,603 |  |  |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | 2,057,393 |  |  |  |  | $ 2,212 |  |  | 2,055,181 |  |  |  |  |  |  |
Stock-based compensation | 26,336,764 |  |  |  |  |  |  |  | 26,336,764 |  |  |  |  |  |  |
Net loss attributable to common stockholders | (303,658,710) |  |  |  |  |  |  |  |  |  |  |  | (303,658,710) |  |  |
Unrealized loss on short-term investments, net of tax | 4,048 |  |  |  |  |  |  |  |  |  |  |  |  |  | 4,048 |
Foreign currency translation | (30,134) |  |  |  |  |  |  |  |  |  |  |  |  |  | (30,134) |
Ending balance (in shares) at Dec. 31, 2021 |  |  |  |  | 9 | 217,382,887 |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2021 | 399,669,421 | $ (1,468,216) |  |  | $ 0 | $ 217,382 |  |  | 1,609,589,797 | $ (3,294,019) |  |  | (1,209,855,522) | $ 1,825,803 | (282,236) | 0
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) |  |  |  |  |  | 34,445,743 |  |  |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs | 82,955,311 |  |  |  |  | $ 34,447 |  |  | 82,920,864 |  |  |  |  |  |  |
Exercise of stock options and warrants for cash and vesting of RSUs, net of tax payments (in shares) |  |  |  |  |  | 1,262,689 |  |  |  |  |  |  |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments | (1,114,609) |  |  |  |  | $ 1,261 |  |  | (1,115,870) |  |  |  |  |  |  |
Stock-based compensation | 22,555,419 |  |  |  |  |  |  |  | 22,555,419 |  |  |  |  |  |  |
Net loss attributable to common stockholders | (279,818,065) |  |  |  |  |  |  |  |  |  |  |  | (279,818,065) |  |  |
Unrealized loss on short-term investments, net of tax | (390,949) |  |  |  |  |  |  |  |  |  |  |  |  |  | (390,949) |
Foreign currency translation | (25,556) |  |  |  |  |  |  |  |  |  |  |  |  |  | (25,556) |
Ending balance (in shares) at Dec. 31, 2022 |  |  |  |  | 9 | 253,091,319 |  |  |  |  |  |  |  |  |  |
Ending balance at Dec. 31, 2022 | $ 222,362,756 |  |  |  | $ 0 | $ 253,090 |  |  | $ 1,710,656,191 |  |  |  | $ (1,487,847,784) |  | $ (698,741) | $ 0

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