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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Deferred tax assets: |  |
Capitalized research expense | $ 41,252 | $ 4,200
NOL carryforwards | 212,768 | 197,144
Research and development and other tax credits | 26,442 | 23,005
Deferred revenue | 538 | 987
Stock-based compensation | 3,945 | 3,599
Acquired intangibles | 559 | 637
Interest expense | 0 | 83
Investment in affiliated entity | 1,569 | 750
Lease liability | 3,247 | 3,793
Fixed assets | 57 | 0
Other | 11,062 | 5,973
Deferred tax assets, gross | 301,439 | 240,171
Valuation allowance | (299,124) | (237,205)
Total deferred tax assets | 2,315 | 2,966
Deferred tax liabilities: |  |
Acquired intangibles | (199) | (194)
Right of use asset | (2,148) | (2,430)
Note discount | 0 | (321)
Fixed assets | 0 | (53)
Total deferred tax liabilities | (2,347) | (2,998)
Net deferred tax liabilities | $ (32) | $ (32)

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