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Income Taxes - Reconciliation of Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract] |  |  |
Benefit from income taxes at statutory rates | $ (58,307) | $ (63,677) | $ (34,207)
State income tax, net of federal benefit | (3,601) | (3,447) | 0
Change in valuation allowance | 61,065 | 77,424 | 21,428
Nondeductible loss on extinguishment of debt | 0 | 0 | 14,450
Research and development tax credits | (7,534) | (16,523) | (2,650)
Stock-based compensation | 2,913 | 483 | (1,953)
Uncertain tax positions | 2,291 | 6,509 | 1,068
Deconsolidation of subsidiary | 0 | 0 | 853
Expired NOLs and credits | 1,459 | 616 | 468
Limited NOLs and credits | (1,337) | (542) | (368)
Change in tax rates | (187) | 0 | 0
Foreign tax rate differential | (8) | (24) | (9)
Other | 3,246 | (819) | 920
Income tax expense (benefit) | $ 0 | $ 0 | $ 0

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319 + Details
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