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Consolidated Statements of Comprehensive Loss - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Statement of Comprehensive Income [Abstract]
Net loss	$ (279,818,065)	$ (303,658,710)	$ (167,474,914)
Other comprehensive (loss) income:
Foreign currency translation	(25,556)	(30,134)	27,205
Unrealized (loss) gain on short-term investments, net of tax	(390,949)	4,048	(755,963)
Comprehensive loss	(280,234,570)	(303,684,796)	(168,203,672)
Comprehensive loss attributable to non-controlling interest	0	0	1,063,757
Comprehensive loss attributable to Inovio Pharmaceuticals, Inc.	$ (280,234,570)	$ (303,684,796)	$ (167,139,915)

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