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Income Taxes - Components of Pretax Loss from Operations (Details) - USD ($)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Tax Disclosure [Abstract]      
U.S. Domestic $ (277,440,803) $ (302,614,003) $ (162,664,355)
Foreign (211,249) (610,320) (225,949)
Net loss before share in net loss of Geneos $ (277,652,052) $ (303,224,323) $ (162,890,304)