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Income Taxes - Reconciliation of Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]
Benefit from income taxes at statutory rates	$ (58,307)	$ (63,677)	$ (34,207)
State income tax, net of federal benefit	(3,601)	(3,447)	0
Change in valuation allowance	61,065	77,424	21,428
Nondeductible loss on extinguishment of debt	0	0	14,450
Research and development tax credits	(7,534)	(16,523)	(2,650)
Stock-based compensation	2,913	483	(1,953)
Uncertain tax positions	2,291	6,509	1,068
Deconsolidation of subsidiary	0	0	853
Expired NOLs and credits	1,459	616	468
Limited NOLs and credits	(1,337)	(542)	(368)
Change in tax rates	(187)	0	0
Foreign tax rate differential	(8)	(24)	(9)
Other	3,246	(819)	920
Income tax expense (benefit)	$ 0	$ 0	$ 0

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Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 740
-SubTopic 10
-Section 50
-Paragraph 12
-URI https://asc.fasb.org/extlink&oid=121826272&loc=d3e32687-109319

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