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v3.23.1

Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022
Cash flows from operating activities: |  |  |
Net loss | $ (40,649,317) | $ (79,073,719) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 707,378 | 929,383 |
Amortization of intangible assets | 82,083 | 126,770 |
Amortization of operating lease right-of-use assets | 362,664 | 319,586 |
Non-cash stock-based compensation | 3,809,003 | 7,711,151 |
Non-cash interest on senior convertible notes | (219,999) | (219,999) |
Amortization of (discounts) premiums on investments | (1,159,083) | 125,810 |
Realized loss on short-term investments | 2,425,676 | 318,684 |
Loss on disposal of fixed assets | 334,297 | 157,666 |
Gain on remeasurement of investment in Geneos | 0 | (165,215) |
(Gain) loss on equity investment in affiliated entity | (616,639) | 537,728 |
Share of net loss in Geneos | 0 | 2,165,213 |
Net unrealized (gain) loss on available-for-sale equity securities | (3,218,215) | 4,840,641 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable, including from affiliated entities | 6,703,110 | 541,248 |
Prepaid expenses and other current assets, including from affiliated entities | 39,324,542 | 7,075,934 |
Other assets | 31,527 | 151,999 |
Accounts payable and accrued expenses, including due to affiliated entities | (40,737,879) | (9,000,559) |
Accrued clinical trial expenses | (4,798,227) | 1,501,489 |
Deferred revenue, including from affiliated entity | 0 | (9,963) |
Operating lease right-of-use assets and liabilities, net | (693,691) | (624,673) |
Grant funding liability, including from affiliated entity | 1,648,292 | 723,550 |
Other liabilities | 0 | (14,826) |
Net cash used in operating activities | (36,664,478) | (61,882,102) |
Cash flows from investing activities: |  |  |
Purchases of investments | (80,431,174) | (99,722,697) |
Proceeds from sale or maturity of investments | 93,657,050 | 123,055,048 |
Purchases of capital assets | (296,983) | 0 |
Proceeds from sale of capital assets | 6,071,000 | 0 |
Investment in Geneos | 0 | (1,999,998) |
Net cash provided by investing activities | 18,999,893 | 21,332,353 |
Cash flows from financing activities: |  |  |
Proceeds from issuance of common stock, net of issuance costs | 0 | 29,364,538 |
Proceeds from stock option exercises | 0 | 83,812 |
Taxes paid related to net share settlement of equity awards | (424,704) | (1,026,333) |
Net cash (used in) provided by financing activities | (424,704) | 28,422,017 |
Effect of exchange rate changes on cash and cash equivalents | (1,918) | (6,555) |
Decrease in cash and cash equivalents | (18,091,207) | (12,134,287) |
Cash and cash equivalents, beginning of period | 46,329,359 | 71,143,778 | $ 71,143,778
Cash and cash equivalents, end of period | 28,238,152 | 59,009,491 | $ 46,329,359
Supplemental disclosures: |  |  |
Amounts accrued for purchases of fixed assets | 0 | 330,779 |
Interest paid | 533,487 | 533,487 |
Issuance of common stock for the legal settlement | $ 14,000,000 | $ 0 |

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