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Basis of Presentation, Liquidity and Risks and Uncertainties (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net loss	$ 40,649,317	$ 79,073,719
Working capital	178,700,000
Accumulated deficit	1,528,497,101		$ 1,487,847,784
Cash, cash equivalents, and short-term investments	223,800,000
Proceeds from issuance of stock	0	$ 29,364,538
Common stock | Sales Agreements
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Proceeds from issuance of stock	$ 0		$ 83,000,000

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