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Stockholders' Equity - Narrative (Details) - USD ($)
$ / shares in Units, $ in Millions
 6 Months Ended
Nov. 09, 2021
Jun. 30, 2023
May 16, 2023
Mar. 31, 2023
Jun. 24, 2022
Class of Stock [Line Items]          
Common stock, shares, issued (in shares)   268,073,202      
McDermid v. Inovio Pharmaceuticals, Inc. and J. Joseph Kim          
Class of Stock [Line Items]          
Common stock, shares, issued (in shares)       9,121,000  
2016 Incentive Plan          
Class of Stock [Line Items]          
Number of shares of unvested restricted stock units and options outstanding (in shares)   3,545,212      
Common stock, other shares, outstanding (in shares)   13,181,949      
Award vesting period (in years)   3 years      
Maximum contractual term (in years)   10 years      
2023 Incentive Plan          
Class of Stock [Line Items]          
Number of shares authorized (in shares)     14,000,000    
Number of shares available for grant (in shares)   14,098,753      
Number of shares of unvested restricted stock units and options outstanding (in shares)   0      
Common stock, other shares, outstanding (in shares)   1,875      
Award vesting period (in years)   3 years      
Maximum contractual term (in years)   10 years      
2022 Inducement Plan          
Class of Stock [Line Items]          
Number of shares authorized (in shares)         2,000,000
Number of shares available for grant (in shares)   1,557,500      
Number of shares of unvested restricted stock units and options outstanding (in shares)   120,000      
Common stock, other shares, outstanding (in shares)   287,500      
2007 Incentive Plan          
Class of Stock [Line Items]          
Common stock, other shares, outstanding (in shares)   1,695,370      
Maximum contractual term (in years)   10 years      
Common stock | Sales Agreement          
Class of Stock [Line Items]          
Maximum authorized amount $ 300.0        
Sale of stock, sales proceeds of any common stock, percentage 3.00%        
Aggregate number of shares issued (in shares)   5,105,152      
Stock sale agreement weighted average price (in dollars per share)   $ 0.58      
Aggregate proceeds   $ 2.9      
Remaining authorized amount   $ 164.4