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Related Party Transactions (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Dec. 31, 2022 | Mar. 31, 2016 | Mar. 31, 2020 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Related Party Transaction [Line Items] |  |  |  |  |  |
Revenue from collaborative arrangements and other contracts, including affiliated entity |  |  |  | $ 832,010 | $ 10,262,268 | $ 1,774,758
Research and development |  |  |  | $ 86,676,563 | $ 187,650,503 | 249,240,324
Plumbline Life Sciences |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |
Number of shares owned (in shares) | 597,808 |  |  | 597,808 | 597,808 |
Ownership percentage | 18.70% |  |  | 17.80% | 18.70% |
Affiliated Entity |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |
Expenses to reimburse |  | $ 3,100,000 |  |  |  |
Term |  | 5 years |  |  |  |
Grant proceeds received |  |  |  | $ 1,000,000 | $ 8,700,000 |
Affiliated Entity | Revenue under collaborative research and development arrangements from affiliated entities |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |
Revenue from collaborative arrangements and other contracts, including affiliated entity |  |  |  | 0 | 34,000 | 245,000
Plumbline Life Sciences | Affiliated Entity |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |
Accounts receivable | $ 59,000 |  |  | 0 | 59,000 |
The Wistar Institute |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |
Agreement amended amount |  |  |  |  |  | 13,600,000
The Wistar Institute | Affiliated Entity |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |
Awarded amount | 1,200,000 |  | $ 10,700,000 |  |  |
Awarded option amount | 5,400,000 |  |  |  |  | 1,600,000
Research and development |  |  |  | 1,800,000 | 1,400,000 | $ 2,900,000
Accounts receivable | 9,900,000 |  |  | 2,400,000 | 9,900,000 |
Accounts payable and accrued expenses | 1,200,000 |  |  | 1,100,000 | 1,200,000 |
Prepaid expense | 375,000 |  |  | 20,000 | 375,000 |
Deferred grant funding from affiliate | $ 88,000 |  |  | $ 22,000 | $ 88,000 |

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