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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Income Tax Disclosure [Abstract] |
Schedule Of Components Of Pretax Loss From Operations | The components of pretax loss from operations are as follows:
| Year Ended December 31,
| 2023 |  | 2022 |  | 2021
U.S. Domestic | $ | (134,979,579) |  |  | $ | (277,440,803) |  |  | $ | (302,614,003) |
Foreign | (137,772) |  |  | (211,249) |  |  | (610,320) |
Pretax loss from operations | $ | (135,117,351) |  |  | $ | (277,652,052) |  |  | $ | (303,224,323) |
Schedule Of Effective Income Tax Rate Reconciliation | The reconciliation of income taxes attributable to continuing operations computed at the statutory tax rates to income tax benefit, using a 21% statutory tax rate for December 31, 2023, 2022 and 2021, is as follows:
| Year Ended December 31,
| 2023 |  | 2022 |  | 2021
Benefit from income taxes at statutory rates | $ | (28,375,000) |  |  | $ | (58,307,000) |  |  | $ | (63,677,000) |
State income tax, net of federal benefit | (3,922,000) |  |  | (3,601,000) |  |  | (3,447,000) |
Change in valuation allowance | 28,394,000 |  |  | 61,065,000 |  |  | 77,424,000 |
Research and development tax credits | (2,139,000) |  |  | (7,534,000) |  |  | (16,523,000) |
Stock-based compensation | 2,099,000 |  |  | 2,913,000 |  |  | 483,000 |
Uncertain tax positions | 861,000 |  |  | 2,291,000 |  |  | 6,509,000 |
Goodwill Impairment | 1,962,000 |  |  | — |  |  | — |
Expired NOLs and credits | 1,352,000 |  |  | 1,459,000 |  |  | 616,000 |
Limited NOLs and credits | (997,000) |  |  | (1,337,000) |  |  | (542,000) |
Change in tax rates | 365,000 |  |  | (187,000) |  |  | — |
Foreign tax rate differential | (4,000) |  |  | (8,000) |  |  | (24,000) |
Other | 404,000 |  |  | 3,246,000 |  |  | (819,000) |
| $ | — |  |  | $ | — |  |  | $ | — |
Schedule Of Deferred Tax Assets And Liabilities | Significant components of the Company’s deferred tax assets and liabilities as of December 31, 2023 and 2022 are shown below:
| As of December 31,
| 2023 |  | 2022
Deferred tax assets: |  |  |
Capitalized research expense | $ | 50,143,000 |  |  | $ | 41,252,000 |
NOL carryforwards | 235,624,000 |  |  | 212,768,000 |
Research and development and other tax credits | 27,734,000 |  |  | 26,442,000 |
Deferred revenue | 22,000 |  |  | 538,000 |
Stock-based compensation | 3,683,000 |  |  | 3,945,000 |
Acquired intangibles | 907,000 |  |  | 559,000 |
Investment in affiliated entity | 1,406,000 |  |  | 1,569,000 |
Lease liability | 2,822,000 |  |  | 3,247,000 |
Fixed assets | 337,000 |  |  | 57,000 |
Other | 6,808,000 |  |  | 11,062,000 |
| 329,486,000 |  |  | 301,439,000 |
Valuation allowance | (327,493,000) |  |  | (299,124,000) |
Total deferred tax assets | 1,993,000 |  |  | 2,315,000 |
Deferred tax liabilities: |  |  |
Acquired intangibles | — |  |  | (199,000) |
Right of use asset | (1,993,000) |  |  | (2,148,000) |
Total deferred tax liabilities | (1,993,000) |  |  | (2,347,000) |
Net deferred tax liabilities | $ | — |  |  | $ | (32,000) |
Schedule Of Operating Loss And Tax Credit Carryforward Expirations | Based upon statute, federal and state losses and credits are expected to expire as follows (in millions):
Expiration Date: | Federal NOLs |  | State NOLs |  | Foreign NOLs |  | Federal R&D |  | State R&D
2024 | $ | 18.9 |  |  | $ | 9.1 |  |  | $ | — |  |  | $ | — |  |  | $ | — |
2025 | 13.7 |  |  | 5.2 |  |  | — |  |  | — |  |  | — |
2026 | 12.2 |  |  | 7.1 |  |  | — |  |  | — |  |  | — |
2027 and thereafter | 249.2 |  |  | 332.0 |  |  | 1.1 |  |  | 41.6 |  |  | — |
Indefinite | 719.3 |  |  | 0.6 |  |  | — |  |  | — |  |  | 6.1 |
| $ | 1,013.3 |  |  | $ | 354.0 |  |  | $ | 1.1 |  |  | $ | 41.6 |  |  | $ | 6.1 |
Schedule Of Unrecognized Tax Benefits Rollforward | The following table summarizes the activity related to the Company's unrecognized tax benefits:
| Year ended December 31,
| 2023 |  | 2022 |  | 2021
Balance at beginning of the year | $ | 21,139,000 |  |  | $ | 18,819,000 |  |  | $ | 12,210,000 |
Increases related to current year tax positions | 1,816,000 |  |  | 2,902,000 |  |  | 6,602,000 |
Increases (decreases) related to prior year tax positions | (841,000) |  |  | (582,000) |  |  | 7,000 |
Balance at end of the year | $ | 22,114,000 |  |  | $ | 21,139,000 |  |  | $ | 18,819,000 |

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