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Related Party Transactions (Details) - USD ($)
 1 Months Ended 3 Months Ended 12 Months Ended
Dec. 31, 2022
Mar. 31, 2016
Mar. 31, 2020
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Related Party Transaction [Line Items]            
Revenue from collaborative arrangements and other contracts, including affiliated entity       $ 832,010 $ 10,262,268 $ 1,774,758
Research and development       $ 86,676,563 $ 187,650,503 249,240,324
Plumbline Life Sciences            
Related Party Transaction [Line Items]            
Number of shares owned (in shares) 597,808     597,808 597,808  
Ownership percentage 18.70%     17.80% 18.70%  
Affiliated Entity            
Related Party Transaction [Line Items]            
Expenses to reimburse   $ 3,100,000        
Term   5 years        
Grant proceeds received       $ 1,000,000 $ 8,700,000  
Affiliated Entity | Revenue under collaborative research and development arrangements from affiliated entities            
Related Party Transaction [Line Items]            
Revenue from collaborative arrangements and other contracts, including affiliated entity       0 34,000 245,000
Plumbline Life Sciences | Affiliated Entity            
Related Party Transaction [Line Items]            
Accounts receivable $ 59,000     0 59,000  
The Wistar Institute            
Related Party Transaction [Line Items]            
Agreement amended amount           13,600,000
The Wistar Institute | Affiliated Entity            
Related Party Transaction [Line Items]            
Awarded amount 1,200,000   $ 10,700,000      
Awarded option amount 5,400,000         1,600,000
Research and development       1,800,000 1,400,000 $ 2,900,000
Accounts receivable 9,900,000     2,400,000 9,900,000  
Accounts payable and accrued expenses 1,200,000     1,100,000 1,200,000  
Prepaid expense 375,000     20,000 375,000  
Deferred grant funding from affiliate $ 88,000     $ 22,000 $ 88,000