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Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2024 | Mar. 31, 2023 | Dec. 31, 2023
Cash flows from operating activities: |  |  |
Net loss | $ (30,469,871) | $ (40,649,317) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 424,473 | 707,378 |
Amortization of intangible assets | 0 | 82,083 |
Amortization of operating lease right-of-use assets | 335,257 | 362,664 |
Non-cash stock-based compensation | 2,525,433 | 3,809,003 |
Non-cash interest on senior convertible notes | (355,654) | (219,999) |
Amortization of discounts on investments | (684,651) | (1,159,083) |
Loss on sales of short-term investments | 691,168 | 2,425,676 |
Loss on disposal of fixed assets | 0 | 334,297 |
Loss (gain) on equity investment in affiliated entity | 126,018 | (616,639) |
Net unrealized gain on available-for-sale equity securities | (500,877) | (3,218,215) |
Changes in operating assets and liabilities: |  |  |
Accounts receivable, including from affiliated entities | (145,854) | 6,703,110 |
Prepaid expenses and other current assets, including from affiliated entities | 1,897,016 | 39,324,542 |
Other assets | 0 | 31,527 |
Accounts payable and accrued expenses, including due to affiliated entities | (3,160,238) | (40,737,879) |
Accrued clinical trial expenses | 657,104 | (4,798,227) |
Operating lease right-of-use assets and liabilities, net | (11,791) | (693,691) |
Grant funding liability, including from affiliated entity | (87,489) | 1,648,292 |
Net cash used in operating activities | (28,759,956) | (36,664,478) |
Cash flows from investing activities: |  |  |
Purchases of investments | (9,751,047) | (80,431,174) |
Proceeds from sale or maturity of investments | 55,169,260 | 93,657,050 |
Purchases of capital assets | (35,578) | (296,983) |
Proceeds from sale of capital assets | 0 | 6,071,000 |
Net cash provided by investing activities | 45,382,635 | 18,999,893 |
Cash flows from financing activities: |  |  |
Repayment of convertible senior notes | (16,415,000) | 0 |
Proceeds from issuance of common stock, net of issuance costs | 5,225,133 | 0 | $ 5,500,000
Taxes paid related to net share settlement of equity awards | (174,248) | (424,704) |
Net cash used in financing activities | (11,364,115) | (424,704) |
Effect of exchange rate changes on cash and cash equivalents | 32,403 | (1,918) |
Increase (Decrease) in cash and cash equivalents | 5,290,967 | (18,091,207) |
Cash and cash equivalents, beginning of period | 14,310,862 | 46,329,359 | 46,329,359
Cash and cash equivalents, end of period | 19,601,829 | 28,238,152 | $ 14,310,862
Supplemental disclosures: |  |  |
Amounts accrued for purchases of fixed assets | 442,976 | 0 |
Interest paid | 533,487 | 533,187 |
Issuance of common stock as part of litigation settlement | $ 0 | $ 14,000,000 |

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