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Condensed Consolidated Statements of Cash Flows - USD ($) | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | ---
Jun. 30, 2024 | Mar. 31, 2024 | Jun. 30, 2023 | Mar. 31, 2023 | Jun. 30, 2024 | Jun. 30, 2023 | Dec. 31, 2023
Cash flows from operating activities: |  |  |  |  |  |  |
Net loss | $ (32,237,098) | $ (30,469,871) | $ (35,534,533) | $ (40,649,317) | $ (62,706,969) | $ (76,183,850) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |  |  |
Depreciation |  |  |  |  | 916,019 | 1,410,649 |
Amortization of intangible assets |  |  |  |  | 0 | 145,417 |
Amortization of operating lease right-of-use assets |  |  |  |  | 672,336 | 739,469 |
Impairment of intangible assets |  |  |  |  | 0 | 1,984,444 |
Non-cash stock-based compensation |  |  |  |  | 4,039,486 | 6,727,000 |
Non-cash interest on senior convertible notes |  |  |  |  | (355,654) | 93,489 |
Amortization of discounts on investments |  |  |  |  | (1,154,822) | (2,402,451) |
Loss on sales of short-term investments |  |  |  |  | 692,557 | 3,853,543 |
Loss on disposal of fixed assets |  |  |  |  | 21,930 | 334,297 |
Loss (gain) on equity investment in affiliated entity | 334,294 |  | (156,745) |  | 460,312 | (773,384) |
Net unrealized gain on available-for-sale equity securities | 20,820 |  | (922,941) |  | (480,057) | (4,141,156) |
Changes in operating assets and liabilities: |  |  |  |  |  |  |
Accounts receivable, including from affiliated entities |  |  |  |  | 631,563 | 6,621,990 |
Prepaid expenses and other current assets, including from affiliated entities |  |  |  |  | 48,237 | 41,191,898 |
Other assets |  |  |  |  | 19,400 | 17,154 |
Accounts payable and accrued expenses, including due to affiliated entities |  |  |  |  | (2,362,045) | (43,955,799) |
Accrued clinical trial expenses |  |  |  |  | 3,134,266 | (4,421,691) |
Operating lease right-of-use assets and liabilities, net |  |  |  |  | (458,376) | (1,406,066) |
Grant funding liability, including from affiliated entity |  |  |  |  | (87,489) | 1,185,913 |
Net cash used in operating activities |  |  |  |  | (56,969,306) | (68,979,134) |
Cash flows from investing activities: |  |  |  |  |  |  |
Purchases of investments |  |  |  |  | (29,359,747) | (106,741,680) |
Proceeds from sale or maturity of investments |  |  |  |  | 85,196,528 | 173,898,007 |
Purchases of capital assets |  |  |  |  | (487,832) | (320,898) |
Proceeds from sale of capital assets |  |  |  |  | 0 | 6,071,000 |
Net cash provided by investing activities |  |  |  |  | 55,348,949 | 72,906,429 |
Cash flows from financing activities: |  |  |  |  |  |  |
Repayment of convertible senior notes |  |  |  |  | (16,415,000) | 0 |
Proceeds from issuance of pre-funded warrants, net of issuance costs |  |  |  |  | 16,146,397 | 0 |
Proceeds from issuance of common stock, net of issuance costs |  | 5,200,000 |  |  | 22,284,801 | 2,915,179 | $ 5,500,000
Proceeds from stock option exercises |  |  |  |  | 67,675 | 0 |
Taxes paid related to net share settlement of equity awards |  |  |  |  | (414,377) | (456,996) |
Net cash provided by financing activities |  |  |  |  | 21,669,496 | 2,458,183 |
Effect of exchange rate changes on cash and cash equivalents |  |  |  |  | 32,403 | (2,294) |
Increase in cash and cash equivalents |  |  |  |  | 20,081,542 | 6,383,184 |
Cash and cash equivalents, beginning of period |  | $ 14,310,862 |  | $ 46,329,359 | 14,310,862 | 46,329,359 | 46,329,359
Cash and cash equivalents, end of period | $ 34,392,404 |  | $ 52,712,543 |  | 34,392,404 | 52,712,543 | $ 14,310,862
Supplemental disclosures: |  |  |  |  |  |  |
Interest paid |  |  |  |  | 533,487 | 533,487 |
Issuance of common stock as part of litigation settlement |  |  |  |  | $ 0 | $ 14,000,000 |

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