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Condensed Consolidated Statements of Stockholders' Equity - USD ($) | Total | Preferred stock | Common stock | Additional paid-in capital | Accumulated deficit | Accumulated other comprehensive loss
--- | --- | --- | --- | --- | --- | ---
Beginning balance (in shares) at Dec. 31, 2022 |  |  | 9 | 21,090,938 | [1] |  |  |
Beginning balance at Dec. 31, 2022 |  | $ 222,362,756 | $ 0 | $ 21,090 | [1] | $ 1,710,888,191 | $ (1,487,847,784) | $ (698,741)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) | [1] |  |  | 760,083 |  |  |  |
Issuance of common stock for cash, net of financing costs |  | 14,000,000 |  | $ 760 | [1] | 13,999,240 |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) | [1] |  |  | 43,901 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments |  | (424,704) |  | $ 44 | [1] | (424,748) |  |
Stock-based compensation |  | 3,809,003 |  |  |  | 3,809,003 |  |
Net loss |  | (40,649,317) |  |  |  |  | (40,649,317) |
Unrealized loss on short-term investments, net of tax |  | 117,862 |  |  |  |  |  | 117,862
Foreign currency translation |  | (1,918) |  |  |  |  |  | (1,918)
Ending balance (in shares) at Mar. 31, 2023 |  |  | 9 | 21,894,922 | [1] |  |  |
Ending balance at Mar. 31, 2023 |  | 199,213,682 | $ 0 | $ 21,894 | [1] | 1,728,271,686 | (1,528,497,101) | (582,797)
Beginning balance (in shares) at Dec. 31, 2022 |  |  | 9 | 21,090,938 | [1] |  |  |
Beginning balance at Dec. 31, 2022 |  | 222,362,756 | $ 0 | $ 21,090 | [1] | 1,710,888,191 | (1,487,847,784) | (698,741)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |
Net loss |  | (76,183,850) |  |  |  |  |  |
Unrealized loss on short-term investments, net of tax |  | 9,773 |  |  |  |  |  |
Foreign currency translation |  | (2,294) |  |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2023 |  |  | 9 | 22,339,428 | [1] |  |  |
Ending balance at Jun. 30, 2023 |  | 169,371,568 | $ 0 | $ 22,338 | [1] | 1,734,072,126 | (1,564,031,634) | (691,262)
Beginning balance (in shares) at Mar. 31, 2023 |  |  | 9 | 21,894,922 | [1] |  |  |
Beginning balance at Mar. 31, 2023 |  | 199,213,682 | $ 0 | $ 21,894 | [1] | 1,728,271,686 | (1,528,497,101) | (582,797)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) | [1] |  |  | 425,429 |  |  |  |
Issuance of common stock for cash, net of financing costs |  | 2,915,179 |  | $ 425 | [1] | 2,914,754 |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) | [1] |  |  | 19,077 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments |  | (32,292) |  | $ 19 | [1] | (32,311) |  |
Stock-based compensation |  | 2,917,997 |  |  |  | 2,917,997 |  |
Net loss |  | (35,534,533) |  |  |  |  | (35,534,533) |
Unrealized loss on short-term investments, net of tax |  | (108,089) |  |  |  |  |  | (108,089)
Foreign currency translation |  | (376) |  |  |  |  |  | (376)
Ending balance (in shares) at Jun. 30, 2023 |  |  | 9 | 22,339,428 | [1] |  |  |
Ending balance at Jun. 30, 2023 |  | 169,371,568 | $ 0 | $ 22,338 | [1] | 1,734,072,126 | (1,564,031,634) | (691,262)
Beginning balance (in shares) at Dec. 31, 2023 |  |  | 9 | 22,793,075 | [1] |  |  |
Beginning balance at Dec. 31, 2023 |  | 117,349,129 | $ 0 | $ 22,792 | [1] | 1,740,954,074 | (1,622,965,136) | (662,601)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) | [1] |  |  | 543,620 |  |  |  |
Issuance of common stock for cash, net of financing costs |  | 5,225,133 |  | $ 544 | [1] | 5,224,589 |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) | [1] |  |  | 34,558 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments |  | (174,248) |  | $ 34 | [1] | (174,282) |  |
Stock-based compensation |  | 2,525,433 |  |  |  | 2,525,433 |  |
Net loss |  | (30,469,871) |  |  |  |  | (30,469,871) |
Unrealized loss on short-term investments, net of tax |  | (46,016) |  |  |  |  |  | (46,016)
Foreign currency translation |  | 32,403 |  |  |  |  |  | 32,403
Ending balance (in shares) at Mar. 31, 2024 |  |  | 9 | 23,371,253 | [1] |  |  |
Ending balance at Mar. 31, 2024 |  | 94,441,963 | $ 0 | $ 23,370 | [1] | 1,748,529,814 | (1,653,435,007) | (676,214)
Beginning balance (in shares) at Dec. 31, 2023 |  |  | 9 | 22,793,075 | [1] |  |  |
Beginning balance at Dec. 31, 2023 |  | 117,349,129 | $ 0 | $ 22,792 | [1] | 1,740,954,074 | (1,622,965,136) | (662,601)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |
Net loss |  | (62,706,969) |  |  |  |  |  |
Unrealized loss on short-term investments, net of tax |  | (59,338) |  |  |  |  |  |
Foreign currency translation |  | 32,403 |  |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2024 |  |  | 9 | 25,963,544 | [1] |  |  |
Ending balance at Jun. 30, 2024 |  | 96,739,207 | $ 0 | $ 25,962 | [1] | 1,783,074,886 | (1,685,672,105) | (689,536)
Beginning balance (in shares) at Mar. 31, 2024 |  |  | 9 | 23,371,253 | [1] |  |  |
Beginning balance at Mar. 31, 2024 |  | 94,441,963 | $ 0 | $ 23,370 | [1] | 1,748,529,814 | (1,653,435,007) | (676,214)
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |  |  |  |  |
Issuance of common stock for cash, net of financing costs (in shares) | [1] |  |  | 2,536,258 |  |  |  |
Issuance of common stock for cash, net of financing costs |  | 17,059,668 |  | $ 2,536 | [1] | 17,057,132 |  |
Issuance of pre-funded warrants for cash, net of financing costs |  | 16,146,397 |  |  |  | 16,146,397 |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments (in shares) | [1] |  |  | 56,033 |  |  |  |
Exercise of stock options for cash and vesting of RSUs, net of tax payments |  | (172,454) |  | $ 56 | [1] | (172,510) |  |
Stock-based compensation |  | 1,514,053 |  |  |  | 1,514,053 |  |
Net loss |  | (32,237,098) |  |  |  |  | (32,237,098) |
Unrealized loss on short-term investments, net of tax |  | (13,322) |  |  |  |  |  | (13,322)
Foreign currency translation |  | 0 |  |  |  |  |  |
Ending balance (in shares) at Jun. 30, 2024 |  |  | 9 | 25,963,544 | [1] |  |  |
Ending balance at Jun. 30, 2024 |  | $ 96,739,207 | $ 0 | $ 25,962 | [1] | $ 1,783,074,886 | $ (1,685,672,105) | $ (689,536)
[1] | All share amounts in this column, including appropriate reclassifications between common stock and additional paid-in capital, have been restated to reflect the 1-for-12 reverse stock split effected in January 2024 on a retroactive basis for all periods presented.

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