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Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
--- | --- | ---
Deferred tax assets: |  |
Capitalized research expense | $ 54,204 | $ 50,143
NOL carryforwards | 250,336 | 235,624
Research and development and other tax credits | 31,250 | 27,734
Deferred revenue | 0 | 22
Stock-based compensation | 3,060 | 3,683
Acquired intangibles | 774 | 907
Investment in affiliated entity | 1,651 | 1,406
Lease liability | 2,492 | 2,822
Fixed assets | 441 | 337
Other | 6,720 | 6,808
Deferred tax assets, gross | 350,928 | 329,486
Valuation allowance | (349,224) | (327,493)
Total deferred tax assets | 1,704 | 1,993
Deferred tax liabilities: |  |
Right of use asset | (1,704) | (1,993)
Total deferred tax liabilities | (1,704) | (1,993)
Net deferred tax liabilities | $ 0 | $ 0

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