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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023
Cash flows from operating activities: |  |
Net loss | $ (107,254,126) | $ (135,117,352)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation | 1,752,147 | 2,621,649
Amortization of intangible assets | 0 | 145,417
Amortization of operating lease right-of-use assets | 1,377,895 | 736,472
Change in fair value of common stock warrant liability | (2,808,608) | 0
Impairment of goodwill | 0 | 10,513,371
Impairment of intangible assets | 0 | 1,984,444
Deferred taxes | 0 | (32,046)
Non-cash stock-based compensation | 6,595,108 | 11,072,486
Non-cash interest on senior convertible notes | (355,654) | 155,814
Amortization of discounts on investments | (1,690,527) | (4,686,144)
Realized loss on sales of short-term investments | 1,905,369 | 4,805,804
Net (gain) loss on disposal of fixed assets | (22,466) | 317,997
Loss (gain) on equity investment in affiliated entity | 1,166,443 | (773,145)
Net unrealized gain on available-for-sale equity securities | (2,077,182) | (5,850,626)
Changes in operating assets and liabilities: |  |
Accounts receivable, including from affiliated entities | 1,206,172 | 9,332,988
Prepaid expenses and other current assets, including from affiliated entities | 1,483,393 | 39,020,611
Other assets | 38,900 | 78,729
Accounts payable and accrued expenses, including due to affiliated entities | (3,367,087) | (45,989,061)
Accrued clinical trial expenses | (343,522) | (8,228,691)
Operating lease right-of-use assets and liabilities, net | (1,573,401) | (2,020,971)
Grant funding liability, including from affiliated entity | (109,407) | (2,453,297)
Net cash used in operating activities | (104,076,553) | (124,365,551)
Cash flows from investing activities: |  |
Purchases of investments | (54,138,026) | (203,475,052)
Proceeds from sale or maturity of investments | 158,637,578 | 284,932,562
Purchases of capital assets | (487,832) | (320,898)
Proceeds from sale of capital assets | 59,319 | 6,219,263
Net cash provided by investing activities | 104,071,039 | 87,355,875
Cash flows from financing activities: |  |
Repayment of convertible senior notes | (16,415,000) | 0
Proceeds from issuance of pre-funded warrants, net of issuance costs | 16,146,397 | 0
Proceeds from issuance of common stock, net of issuance costs | 36,033,473 | 5,461,745
Proceeds from issuance of warrants | 16,063,796 | 0
Proceeds from stock option exercises | 67,675 | 0
Taxes paid related to net share settlement of equity awards | (420,795) | (466,646)
Net cash provided by financing activities | 51,475,546 | 4,995,099
Effect of exchange rate changes on cash and cash equivalents | 32,403 | (3,920)
Increase (decrease) in cash and cash equivalents | 51,502,435 | (32,018,497)
Cash and cash equivalents, beginning of period | 14,310,862 | 46,329,359
Cash and cash equivalents, end of period | 65,813,297 | 14,310,862
Supplemental disclosure: |  |
Interest paid | 533,487 | 1,066,975
Issuance of common stock as part of litigation settlement | $ 0 | $ 14,000,000

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