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v3.25.1

Related Party Transactions (Details) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2024 | Dec. 31, 2022 | Mar. 31, 2016 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2021 | Dec. 31, 2020
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Accounts receivable |  |  |  | $ 1,199,056 | $ 2,405,228 |  |
Research and development |  |  |  | 75,620,340 | 86,676,563 |  |
Affiliated Entity |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Expenses to reimburse |  |  | $ 3,100,000 |  |  |  |
Term |  |  | 5 years |  |  |  |
Grant proceeds received |  |  |  | 482,000 | 1,000,000.0 |  |
Plumbline Life Sciences |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Accounts receivable |  |  |  | 1,600,000 | 2,800,000 |  |
The Wistar Institute |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Agreement amended amount |  |  |  |  |  | $ 13,600,000 |
The Wistar Institute | Affiliated Entity |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Awarded amount |  | $ 1,200,000 |  |  |  |  | $ 10,700,000
Agreement amended amount | $ 12,500,000 |  |  | 2,400,000 |  |  |
Awarded option amount |  | $ 4,200,000 |  |  |  |  |
Research and development |  |  |  | 1,500,000 | 1,800,000 |  |
Accounts receivable |  |  |  | 1,200,000 | 2,400,000 |  |
Accounts payable and accrued expenses |  |  |  | 1,400,000 | 1,100,000 |  |
Prepaid expense |  |  |  | 0 | 20,000 |  |
Deferred grant funding from affiliate |  |  |  | $ 0 | $ 22,000 |  |
Plumbline Life Sciences |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Number of shares owned (in shares) |  |  |  | 597,808 | 597,808 |  |
Ownership percentage |  |  |  | 17.30% | 17.80% |  |

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