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Stockholders' Equity - Stock Options and Restricted Stock Units (Details) - USD ($) | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | May 16, 2023 | Jun. 24, 2022
Class of Stock [Line Items] |  |  |  |
Allocated share-based compensation expense | $ 6,400,000 | $ 10,400,000 |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | $ 2,100,000 | $ 4,300,000 |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition | 1 year 6 months | 1 year 3 months 18 days |  |
Number of options outstanding to purchase common stock (in shares) | 1,337,228 | 1,128,864 |  |
Aggregate intrinsic value of options outstanding | $ 1,000 |  |  |
Aggregate intrinsic value for options exercisable | $ 0 |  |  |
Options exercisable, remaining contractual term | 5 years 6 months |  |  |
Number of options expected to vest (in shares) | 1,337,228 |  |  |
Options, expirations in period, weighted average exercise price (in dollars per share) | $ 139.02 | $ 38.86 |  |
Options, expirations in period (in shares) | 38,503 | 9,357 |  |
Options, grants in period, weighted average grant date fair value (in dollars per share) | $ 6.69 | $ 11.19 |  |
Proceeds from stock option exercises | $ 67,675 | $ 0 |  |
Options, exercises in period, aggregate intrinsic value | 39,000 |  |  |
Nonemployee |  |  |  |
Class of Stock [Line Items] |  |  |  |
Allocated share-based compensation expense | $ 226,000 | $ 669,000 |  |
Number of options outstanding to purchase common stock (in shares) | 66,056 |  |  |
Performance-and market-based restricted stock units |  |  |  |
Class of Stock [Line Items] |  |  |  |
Number of shares of unvested restricted stock units and options outstanding (in shares) | 337,911 | 274,794 |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized | $ 2,000,000.0 | $ 3,500,000 |  |
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition | 1 year 7 months 6 days | 1 year 6 months |  |
Aggregate intrinsic value of unvested | $ 618,000 |  |  |
Aggregate intrinsic value of vested | $ 1,300,000 |  |  |
RSU's expected to vest (in shares) | 337,911 |  |  |
Weighted-average grant date fair value (in USD per share) | $ 8.30 | $ 10.34 |  |
Performance-and market-based restricted stock units | Former President and Chief Executive Officer |  |  |  |
Class of Stock [Line Items] |  |  |  |
Awards settled in cash, percentage | 50.00% |  |  |
Research and Development Expense |  |  |  |
Class of Stock [Line Items] |  |  |  |
Allocated share-based compensation expense | $ 2,800,000 | $ 4,500,000 |  |
General and Administrative Expense |  |  |  |
Class of Stock [Line Items] |  |  |  |
Allocated share-based compensation expense | $ 3,600,000 | $ 5,900,000 |  |
2023 Incentive Plan |  |  |  |
Class of Stock [Line Items] |  |  |  |
Reserved number of shares under the Incentive Plan (in shares) |  |  | 1,166,666 |
Number of shares available for grants under the Incentive Plan (in shares) | 800,526 |  |  |
Number of shares of unvested restricted stock units and options outstanding (in shares) | 188,082 |  |  |
Number of common stock shares outstanding under the Incentive Plan (in shares) | 282,579 |  |  |
Award vesting period (in years) | 3 years |  |  |
Contractual year term of incentive plan (in years) | 10 years |  |  |
2016 Incentive Plan |  |  |  |
Class of Stock [Line Items] |  |  |  |
Number of common stock shares outstanding under the Incentive Plan (in shares) | 904,669 |  |  |
Award vesting period (in years) | 3 years |  |  |
Contractual year term of incentive plan (in years) | 10 years |  |  |
Number of shares of vested restricted stock outstanding under the plan (in shares) | 129,000 |  |  |
2022 Inducement Plan |  |  |  |
Class of Stock [Line Items] |  |  |  |
Reserved number of shares under the Incentive Plan (in shares) |  |  |  | 166,666
Number of shares available for grants under the Incentive Plan (in shares) | 84,328 |  |  |
Number of shares of unvested restricted stock units and options outstanding (in shares) | 20,829 |  |  |
Number of common stock shares outstanding under the Incentive Plan (in shares) | 53,684 |  |  |
2007 Incentive Plan |  |  |  |
Class of Stock [Line Items] |  |  |  |
Number of common stock shares outstanding under the Incentive Plan (in shares) | 96,296 |  |  |
Award vesting period (in years) | 3 years |  |  |
Contractual year term of incentive plan (in years) | 10 years |  |  |

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