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Income Taxes (Tables)
 12 Months Ended
Dec. 31, 2024
Income Tax Disclosure [Abstract]  
Schedule Of Components Of Pretax Loss From Operations
The components of pretax loss from operations are as follows:
Year Ended December 31,
20242023
     U.S. Domestic$(107,254,126)$(134,979,579)
     Foreign— (137,772)
Pretax loss from operations$(107,254,126)$(135,117,351)
Schedule Of Effective Income Tax Rate Reconciliation
The reconciliation of income taxes attributable to continuing operations computed at the statutory tax rates to income tax benefit, using a 21% statutory tax rate for December 31, 2024 and 2023, is as follows: 
Year Ended December 31,
20242023
Benefit from income taxes at statutory rates$(22,523,000)$(28,375,000)
State income tax, net of federal benefit(1,543,000)(3,922,000)
Change in valuation allowance21,749,000 28,394,000 
Research and development tax credits(5,846,000)(2,139,000)
Stock-based compensation1,579,000 2,099,000 
Uncertain tax positions2,344,000 861,000 
Goodwill impairment— 1,962,000 
Expired NOLs and credits4,687,000 1,352,000 
Limited NOLs and credits(2,056,000)(997,000)
Change in tax rates403,000 365,000 
Foreign tax rate differential— (4,000)
Other1,206,000 404,000 
$— $— 
Schedule Of Deferred Tax Assets And Liabilities
Significant components of the Company’s deferred tax assets and liabilities as of December 31, 2024 and 2023 are shown below:
As of December 31,
20242023
Deferred tax assets:
Capitalized research expense$54,204,000 $50,143,000 
NOL carryforwards250,336,000 235,624,000 
Research and development and other tax credits31,250,000 27,734,000 
Deferred revenue— 22,000 
Stock-based compensation3,060,000 3,683,000 
Acquired intangibles774,000 907,000 
Investment in affiliated entity1,651,000 1,406,000 
Lease liability2,492,000 2,822,000 
Fixed assets441,000 337,000 
Other6,720,000 6,808,000 
350,928,000 329,486,000 
Valuation allowance(349,224,000)(327,493,000)
Total deferred tax assets1,704,000 1,993,000 
Deferred tax liabilities:
Right of use asset(1,704,000)(1,993,000)
Total deferred tax liabilities(1,704,000)(1,993,000)
Net deferred tax liabilities$— $— 
Schedule Of Operating Loss And Tax Credit Carryforward Expirations
Based upon statute, federal and state losses and credits are expected to expire as follows (in millions):
Expiration Date:Federal NOLsState NOLsForeign NOLsFederal R&DState R&D
2025$16.0 $5.2 $— $— $— 
202617.1 7.1 — — — 
20276.1 1.9 — — — 
2028 and thereafter245.9 333.6 1.0 46.1 — 
Indefinite801.9 0.7 — — 7.9 
$1,087.0 $348.5 $1.0 $46.1 $7.9 
Schedule Of Unrecognized Tax Benefits Rollforward
The following table summarizes the activity related to the Company's unrecognized tax benefits:
 Year ended December 31,
 20242023
Balance at beginning of the year$22,114,000 $21,139,000 
Increases related to current year tax positions2,297,000 1,816,000 
Increases (decreases) related to prior year tax positions197,000 (841,000)
Balance at end of the year$24,608,000 $22,114,000