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Stockholders' Equity - Stock Options and Restricted Stock Units (Details) - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
May 16, 2023
Jun. 24, 2022
Class of Stock [Line Items]        
Allocated share-based compensation expense $ 6,400,000 $ 10,400,000    
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized $ 2,100,000 $ 4,300,000    
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition 1 year 6 months 1 year 3 months 18 days    
Number of options outstanding to purchase common stock (in shares) 1,337,228 1,128,864    
Aggregate intrinsic value of options outstanding $ 1,000      
Aggregate intrinsic value for options exercisable $ 0      
Options exercisable, remaining contractual term 5 years 6 months      
Number of options expected to vest (in shares) 1,337,228      
Options, expirations in period, weighted average exercise price (in dollars per share) $ 139.02 $ 38.86    
Options, expirations in period (in shares) 38,503 9,357    
Options, grants in period, weighted average grant date fair value (in dollars per share) $ 6.69 $ 11.19    
Proceeds from stock option exercises $ 67,675 $ 0    
Options, exercises in period, aggregate intrinsic value 39,000      
Nonemployee        
Class of Stock [Line Items]        
Allocated share-based compensation expense $ 226,000 $ 669,000    
Number of options outstanding to purchase common stock (in shares) 66,056      
Performance-and market-based restricted stock units        
Class of Stock [Line Items]        
Number of shares of unvested restricted stock units and options outstanding (in shares) 337,911 274,794    
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized $ 2,000,000.0 $ 3,500,000    
Employee service share-based compensation, nonvested awards, total compensation cost not yet recognized, period for recognition 1 year 7 months 6 days 1 year 6 months    
Aggregate intrinsic value of unvested $ 618,000      
Aggregate intrinsic value of vested $ 1,300,000      
RSU's expected to vest (in shares) 337,911      
Weighted-average grant date fair value (in USD per share) $ 8.30 $ 10.34    
Performance-and market-based restricted stock units | Former President and Chief Executive Officer        
Class of Stock [Line Items]        
Awards settled in cash, percentage 50.00%      
Research and Development Expense        
Class of Stock [Line Items]        
Allocated share-based compensation expense $ 2,800,000 $ 4,500,000    
General and Administrative Expense        
Class of Stock [Line Items]        
Allocated share-based compensation expense $ 3,600,000 $ 5,900,000    
2023 Incentive Plan        
Class of Stock [Line Items]        
Reserved number of shares under the Incentive Plan (in shares)     1,166,666  
Number of shares available for grants under the Incentive Plan (in shares) 800,526      
Number of shares of unvested restricted stock units and options outstanding (in shares) 188,082      
Number of common stock shares outstanding under the Incentive Plan (in shares) 282,579      
Award vesting period (in years) 3 years      
Contractual year term of incentive plan (in years) 10 years      
2016 Incentive Plan        
Class of Stock [Line Items]        
Number of common stock shares outstanding under the Incentive Plan (in shares) 904,669      
Award vesting period (in years) 3 years      
Contractual year term of incentive plan (in years) 10 years      
Number of shares of vested restricted stock outstanding under the plan (in shares) 129,000      
2022 Inducement Plan        
Class of Stock [Line Items]        
Reserved number of shares under the Incentive Plan (in shares)       166,666
Number of shares available for grants under the Incentive Plan (in shares) 84,328      
Number of shares of unvested restricted stock units and options outstanding (in shares) 20,829      
Number of common stock shares outstanding under the Incentive Plan (in shares) 53,684      
2007 Incentive Plan        
Class of Stock [Line Items]        
Number of common stock shares outstanding under the Incentive Plan (in shares) 96,296      
Award vesting period (in years) 3 years      
Contractual year term of incentive plan (in years) 10 years