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Income Taxes - Narrative (Details) - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2018
Operating Loss Carryforwards [Line Items]        
Income tax expense (benefit) $ 0 $ 0 $ 0  
Tax benefits expired 5,300,000      
Unrecognized tax benefits that would impact effective tax rate 22,900,000 $ 20,500,000    
Federal        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforwards that will expire due to IRC Section 382 limitations 1,100,000,000      
Federal | Research Tax Credit Carryforward        
Operating Loss Carryforwards [Line Items]        
Tax credit carryforward amount 46,100,000      
California        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforwards that will expire due to IRC Section 382 limitations 259,900,000      
Pennsylvania        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforwards that will expire due to IRC Section 382 limitations 88,600,000      
Federal        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforwards 1,087,000,000     $ 801,900,000
Federal | Research Tax Credit Carryforward        
Operating Loss Carryforwards [Line Items]        
Tax credit carryforward amount 46,100,000      
Foreign Tax Jurisdiction        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforwards 1,000,000      
State        
Operating Loss Carryforwards [Line Items]        
Net operating loss carryforwards 348,500,000      
State | Research Tax Credit Carryforward        
Operating Loss Carryforwards [Line Items]        
Tax credit carryforward amount $ 7,900,000