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Basis of Presentation, Liquidity and Risks and Uncertainties (Details) - USD ($)
 3 Months Ended 12 Months Ended
Dec. 16, 2024
Apr. 18, 2024
Mar. 31, 2025
Mar. 31, 2024
Dec. 31, 2024
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Net loss     $ 19,694,697 $ 30,469,871  
Working capital     44,600,000    
Accumulated deficit     $ 1,749,913,959   $ 1,730,219,262
Common stock, par value (in dollars per share)     $ 0.001   $ 0.001
Cash, cash equivalents, and short-term investments     $ 68,400,000    
Proceeds from issuance of stock     1,102,149 $ 5,225,133  
Underwritten Registered Direct Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Proceeds from sale of stock   $ 33,200,000      
2024 Sales Agreement | Common stock          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Proceeds from issuance of stock     $ 1,100,000   $ 6,100,000
December 2024 Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Consideration received on transaction $ 27,600,000        
Common stock          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Common stock, par value (in dollars per share) $ 0.001        
Proceeds from issuance of stock         $ 60,800,000
Common stock | Underwritten Registered Direct Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Number of shares issued in transaction (in shares)   2,536,258      
Common stock, par value (in dollars per share)   $ 0.001      
Sale of stock, price per share (in dollars per share)   $ 7.693      
Common stock | December 2024 Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Number of shares issued in transaction (in shares) 10,000,000        
Warrants to purchase common stock | Underwritten Registered Direct Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Number of shares issued in transaction (in shares)   2,135,477      
Sale of stock, price per share (in dollars per share)   $ 7.692      
Warrant exercise price (in dollars per share)   $ 0.001      
December 2024 Offering Warrants          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Warrant exercise price (in dollars per share) $ 3.76        
December 2024 Offering Warrants | December 2024 Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Sale of stock, price per share (in dollars per share) 3.00        
Warrant exercise price (in dollars per share) $ 3.76        
December 2024 Offering Warrants | Common stock | December 2024 Offering          
New Accounting Pronouncements or Change in Accounting Principle [Line Items]          
Number of securities called by warrants or rights (in shares) 10,000,000