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Related Party Transactions (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Aug. 31, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Jun. 30, 2025 | Jun. 30, 2024 | Dec. 31, 2024 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2016
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Accounts receivable |  | $ 840,312 |  | $ 840,312 |  | $ 1,199,056 |  |  |  |
Research and development expenses |  | 14,521,407 | $ 23,090,989 | 30,612,309 | $ 44,001,307 |  |  |  |  |
Affiliated Entity |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Expenses to reimburse |  |  |  |  |  |  |  |  |  | $ 3,100,000
Collaborative arrangement, term (in years) |  |  |  |  |  |  |  |  |  | 5 years
Contra-research and development expense |  | $ 315,000 | 9,000 | $ 601,000 | 149,000 |  |  |  |  |
Plumbline Life Sciences |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Investment owned (in shares) |  | 597,808 |  | 597,808 |  |  |  |  |  |
Non-controlling interest (in percent) |  | 15.70% |  | 15.70% |  |  |  |  |  |
Plumbline Life Sciences |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Accounts receivable |  | $ 3,100,000 |  | $ 3,100,000 |  | 1,600,000 |  |  |  |
The Wistar Institute |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Collaborative agreement, amended amount |  |  |  |  |  |  |  | $ 13,600,000 |  |
The Wistar Institute | Affiliated Entity |  |  |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |
Accounts receivable |  | 836,000 |  | 836,000 |  | 1,200,000 |  |  |  |
Awarded amount |  |  |  | 2,600,000 |  | 2,400,000 | $ 1,200,000 |  | $ 10,700,000 |
Collaborative agreement, amended amount | $ 12,500,000 |  |  |  |  |  |  |  |  |
Awarded option amount |  |  |  |  |  | 4,000,000 |  |  |  |
Research and development expenses |  | 72,000 | $ 455,000 | 72,000 | $ 1,000,000 |  |  |  |  |
Accounts payable and accrued liabilities, current |  | $ 369,000 |  | $ 369,000 |  | $ 1,400,000 |  |  |  |

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