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Related Party Transactions (Details) - USD ($) | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2025 | Sep. 30, 2024 | Sep. 30, 2025 | Sep. 30, 2024 | Dec. 31, 2024 | Dec. 31, 2022 | Dec. 31, 2020 | Dec. 31, 2016
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Accounts receivable | $ 978,590 |  | $ 978,590 |  | $ 1,199,056 |  |  |
Research and development expenses | 13,333,329 | $ 18,733,584 | 43,945,638 | $ 62,734,891 |  |  |  |
Grant funding liability from affiliated entity | 42,152 |  | 42,152 |  | 0 |  |  |
Affiliated Entity |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Expenses to reimburse |  |  |  |  |  |  |  | $ 3,100,000
Collaborative arrangement, term (in years) |  |  |  |  |  |  |  | 5 years
Contra-research and development expense | $ 220,000 | 153,000 | $ 821,000 | 302,000 |  |  |  |
Plumbline Life Sciences |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Investment owned (in shares) | 597,808 |  | 597,808 |  |  |  |  |
Non-controlling interest (in percent) | 15.70% |  | 15.70% |  |  |  |  |
Plumbline Life Sciences |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Accounts receivable | $ 2,500,000 |  | $ 2,500,000 |  | 1,600,000 |  |  |
The Wistar Institute | Affiliated Entity |  |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |
Accounts receivable | 979,000 |  | 979,000 |  | 1,200,000 |  |  |
Collaborative agreement, amended amount |  |  |  |  |  |  | $ 12,500,000 |
Awarded amount |  |  | 2,600,000 |  | 2,400,000 | $ 1,200,000 |  |
Awarded option amount |  |  | 4,000,000 |  |  |  |  |
Research and development expenses | 63,000 | $ 296,000 | 135,000 | $ 1,300,000 |  |  |  |
Accounts payable and accrued liabilities, current | $ 380,000 |  | $ 380,000 |  | $ 1,400,000 |  |  |

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