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v3.25.3

Basis of Presentation, Liquidity and Risks and Uncertainties (Details) - USD ($) |  |  |  | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | --- | --- | --- | ---
Jul. 07, 2025 | Dec. 16, 2024 | Apr. 18, 2024 | Sep. 30, 2025 | Jun. 30, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Jun. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2025 | Sep. 30, 2024 | Dec. 31, 2024
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Net loss |  |  |  | $ 45,496,672 | $ 23,519,412 | $ 19,694,697 | $ 25,165,478 | $ 32,237,098 | $ 30,469,871 | $ 88,710,781 | $ 87,872,447 |
Working capital |  |  |  | (14,600,000) |  |  |  |  |  | (14,600,000) |  |
Accumulated deficit |  |  |  | $ 1,818,930,043 |  |  |  |  |  | $ 1,818,930,043 |  | $ 1,730,219,262
Common stock, par value (in dollars per share) |  |  |  | $ 0.001 |  |  |  |  |  | $ 0.001 |  | $ 0.001
Cash, cash equivalents, and short-term investments |  |  |  | $ 50,800,000 |  |  |  |  |  | $ 50,800,000 |  |
Proceeds from issuance of stock |  |  |  |  |  |  |  |  |  | $ 8,287,277 | $ 22,951,867 |
Common stock |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) |  | $ 0.001 |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of stock |  |  |  |  |  |  |  |  |  |  |  | $ 60,800,000
December 2024 Offering Warrants |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) |  | $ 3.76 |  |  |  |  |  |  |  |  |  |
July 2025 Offering |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) | 14,285,715 |  |  |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) | $ 0.001 |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) | 0.001 |  |  |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) | $ 1.75 |  |  |  |  |  |  |  |  |  |  |
Proceeds from sale of stock | $ 22,400,000 |  |  |  |  |  |  |  |  |  |  |
July 2025 Offering | Series A Warrants |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants or rights (in shares) | 14,285,715 |  |  |  |  |  |  |  |  |  |  |
Class of warrant or right, number of securities called by each warrant or right (in shares) | 1 |  |  |  |  |  |  |  |  |  |  |
Pre-funded, exercise price (in USD per share) | $ 0.001 |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) | 1.75 |  |  | $ 1.75 |  |  |  |  |  | $ 1.75 |  |
Sale of stock, price per share (in dollars per share) | $ 1.749 |  |  |  |  |  |  |  |  |  |  |
July 2025 Offering | Series B Warrants |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants or rights (in shares) | 14,285,715 |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) | $ 1.75 |  |  | 1.75 |  |  |  |  |  | 1.75 |  |
Sale of stock, price per share (in dollars per share) | $ 1.749 |  |  |  |  |  |  |  |  |  |  |
December 2024 Offering |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Consideration received on transaction |  | $ 27,600,000 |  |  |  |  |  |  |  |  |  |
December 2024 Offering | Common stock |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  | 10,000,000 |  |  |  |  |  |  |  |  |  |
December 2024 Offering | December 2024 Offering Warrants |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) |  | $ 3.76 |  |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) |  | $ 3.00 |  |  |  |  |  |  |  |  |  |
December 2024 Offering | December 2024 Offering Warrants | Common stock |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of securities called by warrants or rights (in shares) |  | 10,000,000 |  |  |  |  |  |  |  |  |  |
Underwritten Registered Direct Offering |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from sale of stock |  |  | $ 33,200,000 |  |  |  |  |  |  |  |  |
Underwritten Registered Direct Offering | Common stock |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  |  | 2,536,258 |  |  |  |  |  |  |  |  |
Common stock, par value (in dollars per share) |  |  | $ 0.001 |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) |  |  | $ 7.693 |  |  |  |  |  |  |  |  |
Underwritten Registered Direct Offering | Warrants to purchase common stock |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Number of shares issued in transaction (in shares) |  |  | 2,135,477 |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) |  |  | $ 0.001 |  |  |  |  |  |  |  |  |
Sale of stock, price per share (in dollars per share) |  |  | $ 7.692 |  |  |  |  |  |  |  |  |
Underwritten Registered Direct Offering | December 2024 Offering Warrants |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Warrant exercise price (in dollars per share) |  |  |  | $ 3.76 |  |  |  |  |  | $ 3.76 |  |
2024 Sales Agreement | Common stock |  |  |  |  |  |  |  |  |  |  |  |
New Accounting Pronouncements or Change in Accounting Principle [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from issuance of stock |  |  |  |  |  |  |  |  |  | $ 1,100,000 |  | $ 6,100,000

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