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Related Party Transactions (Details) - USD ($)
 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2025
Sep. 30, 2024
Sep. 30, 2025
Sep. 30, 2024
Dec. 31, 2024
Dec. 31, 2022
Dec. 31, 2020
Dec. 31, 2016
Related Party Transaction [Line Items]                
Accounts receivable $ 978,590   $ 978,590   $ 1,199,056      
Research and development expenses 13,333,329 $ 18,733,584 43,945,638 $ 62,734,891        
Grant funding liability from affiliated entity 42,152   42,152   0      
Affiliated Entity                
Related Party Transaction [Line Items]                
Expenses to reimburse               $ 3,100,000
Collaborative arrangement, term (in years)               5 years
Contra-research and development expense $ 220,000 153,000 $ 821,000 302,000        
Plumbline Life Sciences                
Related Party Transaction [Line Items]                
Investment owned (in shares) 597,808   597,808          
Non-controlling interest (in percent) 15.70%   15.70%          
Plumbline Life Sciences                
Related Party Transaction [Line Items]                
Accounts receivable $ 2,500,000   $ 2,500,000   1,600,000      
The Wistar Institute | Affiliated Entity                
Related Party Transaction [Line Items]                
Accounts receivable 979,000   979,000   1,200,000      
Collaborative agreement, amended amount             $ 12,500,000  
Awarded amount     2,600,000   2,400,000 $ 1,200,000    
Awarded option amount     4,000,000          
Research and development expenses 63,000 $ 296,000 135,000 $ 1,300,000        
Accounts payable and accrued liabilities, current $ 380,000   $ 380,000   $ 1,400,000