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Pay vs Performance Disclosure - USD ($)

12 Months Ended

Dec. 31, 2024

Dec. 31, 2023

Dec. 31, 2022



Year	Summary Compensation Table Total for J. Joseph Kim Ph.D.¹ ($)	Summary Compensation Table Total for Jacqueline E. Shea, Ph.D.1 ($)	Compensation Actually Paid to J. Joseph Kim Ph.D.1,2,3 ($)	Compensation Actually Paid to Jacqueline E. Shea, Ph.D.1,2,3 ($)	Average Summary Compensation Table Total for Non-PEO NEOs1 ($)	Average Compensation Actually Paid to Non-PEO NEOs1,2,3 ($)	Value of Initial Fixed $100 Investment based on:4	Net Loss ($ Millions)
							TSR ($)
(a)	(b)	(c)	(b)	(c)	(d)	(e)	(f)	(h)

2024	—	2,050,669	—	904,044	988,739	499,492	3.06	(107)
2023	—	2,438,908	—	1,146,269	1,152,984	725,423	10.22	(135)
2022	10,472,297	3,519,118	3,423,566	1,791,933	1,594,465	433,726	31.26	(280)

Named Executive Officers, Footnote

Dr. Kim was our PEO until May 2022 and his compensation disclosed includes severance benefits. Dr. Shea has served as our PEO since Dr. Kim's departure in May 2022. The individuals comprising the Non-PEO NEOs for each year presented are listed below.

2022

2023

2024

Peter D. Kies

Laurent M. Humeau, Ph.D.

Michael Sumner, M.D.

Adjustment To PEO Compensation, Footnote

Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the Non-PEO NEOs as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718. Amounts in the Exclusion of Stock Awards and Option Awards column are the totals from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table for the applicable year. The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant.



Year	Summary Compensation Table Total for Jacqueline E. Shea, Ph.D. ($)	Exclusion of Stock Awards and Option Awards for Jacqueline E. Shea, Ph.D. ($)	Inclusion of Equity Values for Jacqueline E. Shea, Ph.D. ($)	Compensation Actually Paid to Jacqueline E. Shea, Ph.D. ($)


2024	2,050,669	(966,796)	(179,829)	904,044
2023	2,438,908	(1,304,872)	12,233	1,146,269
2022	3,519,118	(2,439,836)	712,651	1,791,933



Year	Summary Compensation Table Total for J. Joseph Kim Ph.D. ($)	Exclusion of Stock Awards and Option Awards for J. Joseph Kim Ph.D. ($)	Inclusion of Equity Values for J. Joseph Kim Ph.D. ($)	Compensation Actually Paid to J. Joseph Kim Ph.D. ($)

2022	10,472,297	(7,241,702)	192,971	3,423,566



Year	Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Jacqueline E. Shea, Ph.D. ($)	Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Jacqueline E. Shea, Ph.D. ($)	Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Jacqueline E. Shea, Ph.D. ($)	Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Jacqueline E. Shea, Ph.D. ($)	Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Jacqueline E. Shea, Ph.D. ($)	Total - Inclusion of Equity Values for Jacqueline E. Shea, Ph.D. ($)


2024	186,973	(424,136)	113,358	(56,024)	—	(179,829)
2023	558,517	(572,726)	196,121	(169,679)	—	12,233
2022	1,152,757	(489,895)	311,544	(261,755)	—	712,651



Year	Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for J. Joseph Kim Ph.D. ($)	Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for J. Joseph Kim Ph.D. ($)	Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for J. Joseph Kim Ph.D. ($)	Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for J. Joseph Kim Ph.D. ($)	Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for J. Joseph Kim Ph.D. ($)	Total - Inclusion of Equity Values for J. Joseph Kim Ph.D. ($)

2022	470,156	(426,352)	1,538,977	(1,389,810)	—	192,971

Non-PEO NEO Average Total Compensation Amount

$ 988,739

$ 1,152,984

$ 1,594,465

Non-PEO NEO Average Compensation Actually Paid Amount

$ 499,492

725,423

433,726

Adjustment to Non-PEO NEO Compensation Footnote



Year	Average Summary Compensation Table Total for Non-PEO NEOs ($)	Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($)	Average Inclusion of Equity Values for Non-PEO NEOs ($)	Average Compensation Actually Paid to Non-PEO NEOs ($)

2024	988,739	(267,928)	(221,319)	499,492
2023	1,152,984	(350,845)	(76,716)	725,423
2022	1,594,465	(913,308)	(247,431)	433,726



Year	Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($)	Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($)	Average Vesting-Date Fair Value of Equity Awards Granted During Year that Vested During Year for Non-PEO NEOs ($)	Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($)	Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($)	Total - Average Inclusion of Equity Values for Non-PEO NEOs ($)

2024	58,098	(247,419)	30,482	(62,480)	—	(221,319)
2023	150,171	(218,354)	52,732	(61,265)	—	(76,716)
2022	382,936	(489,895)	112,370	(252,842)	—	(247,431)

Compensation Actually Paid vs. Total Shareholder Return

Compensation Actually Paid vs. Net Income

Total Shareholder Return Amount

$ 3.06

10.22

31.26

Net Income (Loss)

$ (107,000,000)

$ (135,000,000)

(280,000,000)

PEO Name

Dr. Shea

Additional 402(v) Disclosure

The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K and do not reflect compensation actually earned, realized, or received by the Company’s NEOs. These amounts reflect the Summary Compensation Table Total for the applicable year with certain adjustments as described in footnote 3 below. The Compensation Committee did not consider Compensation Actually Paid or other disclosure below in making its pay decisions for any of the years shown.Assumes $100 was invested in common stock of the Company for the period starting December 31, 2021, through the end of the listed year. Historical stock performance is not necessarily indicative of future stock performance.